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3ffl
From Proteopedia
(Difference between revisions)
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==Crystal Structure of the N-terminal Domain of Anaphase-Promoting Complex Subunit 7== | ==Crystal Structure of the N-terminal Domain of Anaphase-Promoting Complex Subunit 7== | ||
| - | <StructureSection load='3ffl' size='340' side='right' caption='[[3ffl]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3ffl' size='340' side='right'caption='[[3ffl]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ffl]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ffl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFL FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ANAPC7, APC7 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ANAPC7, APC7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffl OCA], [https://pdbe.org/3ffl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffl RCSB], [https://www.ebi.ac.uk/pdbsum/3ffl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffl ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/APC7_HUMAN APC7_HUMAN]] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Han, D]] | [[Category: Han, D]] | ||
[[Category: Kim, K]] | [[Category: Kim, K]] | ||
Revision as of 07:39, 10 November 2021
Crystal Structure of the N-terminal Domain of Anaphase-Promoting Complex Subunit 7
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