399d
From Proteopedia
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[[Image:399d.gif|left|200px]] | [[Image:399d.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_399d| PDB=399d | SCENE= }} | |
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'''STRUCTURE OF D(CGCCCGCGGGCG)''' | '''STRUCTURE OF D(CGCCCGCGGGCG)''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=399D OCA]. | |
==Reference== | ==Reference== | ||
Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9917405 9917405] | Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9917405 9917405] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Fernandez, L G.]] | [[Category: Fernandez, L G.]] | ||
[[Category: Malinina, J A.Subirana L.]] | [[Category: Malinina, J A.Subirana L.]] | ||
| - | [[Category: | + | [[Category: Double helix]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:18:58 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:18, 4 May 2008
STRUCTURE OF D(CGCCCGCGGGCG)
Overview
We have determined the structure of the dodecamer duplex d(CGCCCGCGGGCG)2. A careful use of the molecular replacement programme AMoRe has been essential in order to solve the structure. This dodecamer shows a unique conformation, quite different from all the previously studied oligonucleotide duplexes: the central octamer has an A conformation, but with a sharp 65 degrees kink in the centre; the terminal base-steps have a B-like conformation; the major groove is completely closed in the centre, a hollow molecule is thus found. The results obtained confirm the high degree of variability of DNA structure. A new type of kink and an intermediate A/B double-helical conformation have been found. Such intermediate conformation differs from those described in DNA polymerase complexes.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:9917405 Page seeded by OCA on Sun May 4 20:18:58 2008
