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<ref name="designing immunotherapies to thwart drug abuse">PMID: 19592672</ref> | <ref name="designing immunotherapies to thwart drug abuse">PMID: 19592672</ref> | ||
<ref name="antibody pharmacokinetics and pharmacodynamics">PMID: 15389672</ref> | <ref name="antibody pharmacokinetics and pharmacodynamics">PMID: 15389672</ref> | ||
| + | <ref name="Immunotherapy for the treatment of drug abuse">DOI: 10.1016/j.pharmthera.2005.06.009</ref> | ||
| + | <ref name="quantitative determination of total methamphetamine and active metabolites in Rat tissue by liquid chromatography with tandem mass spectrometric detection">PMID: 17233534 </ref> | ||
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Revision as of 06:08, 8 December 2018
Contents |
Immunotherapy for treating Methamphetamine Abuse
Introduction
Two major approaches to developing drug-specific immunotherapies: active and passive immunization
Antibody pharmacokinetics, pharmacodynamics and metabolism of therapeutic and diagnostic antibodies
Generation of anti-(+)methamphetamine antibodies during active immunization of rats
Function
Disease
Relevance
Structural highlights
Aromatic-Aromatic Interaction: A Mechanism of Protein Structure Stabilization
| |||||||||
| scFv6H4 in complex with amphetamine | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||||
| Gene: | IgG (LK3 transgenic mice) | ||||||||
| Activity: | , | ||||||||
| Related: | 3gkz, 4laq, 4las | ||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
References
[1] [2] [3] [4] [5] [6] [7] [7] [7] [7] [7] [7] [7] [7] [7] [7] PMID:
- ↑ Burley SK, Petsko GA. Aromatic-aromatic interaction: a mechanism of protein structure stabilization. Science. 1985 Jul 5;229(4708):23-8. PMID:3892686
- ↑ doi: https://dx.doi.org/10.1016/S1567-5769(00)00019-9
- ↑ Peterson EC, Owens SM. Designing immunotherapies to thwart drug abuse. Mol Interv. 2009 Jun;9(3):119-24. doi: 10.1124/mi.9.3.5. PMID:19592672 doi:http://dx.doi.org/10.1124/mi.9.3.5
- ↑ Lobo ED, Hansen RJ, Balthasar JP. Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci. 2004 Nov;93(11):2645-68. doi: 10.1002/jps.20178. PMID:15389672 doi:http://dx.doi.org/10.1002/jps.20178
- ↑ Kosten T, Owens SM. Immunotherapy for the treatment of drug abuse. Pharmacol Ther. 2005 Oct;108(1):76-85. doi: 10.1016/j.pharmthera.2005.06.009. PMID:16023218 doi:http://dx.doi.org/10.1016/j.pharmthera.2005.06.009
- ↑ Hendrickson H, Laurenzana E, Owens SM. Quantitative determination of total methamphetamine and active metabolites in rat tissue by liquid chromatography with tandem mass spectrometric detection. AAPS J. 2006 Nov 22;8(4):E709-17. doi: 10.1208/aapsj080480. PMID:17233534 doi:http://dx.doi.org/10.1208/aapsj080480
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 . PMID:216315890657
