6n89
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the Importin beta:Histone H1.0 complex== | |
| - | + | <StructureSection load='6n89' size='340' side='right' caption='[[6n89]], [[Resolution|resolution]] 7.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n89]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N89 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6n88|6n88]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n89 OCA], [http://pdbe.org/6n89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n89 RCSB], [http://www.ebi.ac.uk/pdbsum/6n89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n89 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IMB1_HUMAN IMB1_HUMAN]] Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus.<ref>PMID:9687515</ref> <ref>PMID:10228156</ref> <ref>PMID:11891849</ref> [[http://www.uniprot.org/uniprot/H10_HUMAN H10_HUMAN]] Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bilokapic, S]] | ||
[[Category: Halic, M]] | [[Category: Halic, M]] | ||
| - | [[Category: Bilokapic, S]] | ||
[[Category: Ivic, N]] | [[Category: Ivic, N]] | ||
| + | [[Category: Disordered interaction]] | ||
| + | [[Category: Histone h1]] | ||
| + | [[Category: Imp7:impb:h1 0]] | ||
| + | [[Category: Importin]] | ||
| + | [[Category: Nuclear import]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 15:30, 27 February 2019
Cryo-EM structure of the Importin beta:Histone H1.0 complex
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