3bb7

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[[Image:3bb7.gif|left|200px]]
[[Image:3bb7.gif|left|200px]]
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{{Structure
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|PDB= 3bb7 |SIZE=350|CAPTION= <scene name='initialview01'>3bb7</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_3bb7", creates the "Structure Box" on the page.
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|SITE=
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|GENE= PIN0048 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28131 Prevotella intermedia])
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|DOMAIN=
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{{STRUCTURE_3bb7| PDB=3bb7 | SCENE= }}
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|RELATEDENTRY=[[3bba|3BBA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bb7 OCA], [http://www.ebi.ac.uk/pdbsum/3bb7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bb7 RCSB]</span>
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'''Structure of Prevotella intermedia prointerpain A fragment 39-359 (mutant C154A)'''
'''Structure of Prevotella intermedia prointerpain A fragment 39-359 (mutant C154A)'''
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[[Category: Uson, I.]]
[[Category: Uson, I.]]
[[Category: Wawrzonek, K.]]
[[Category: Wawrzonek, K.]]
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[[Category: bacterial odontopathogen]]
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[[Category: Bacterial odontopathogen]]
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[[Category: cysteine protease]]
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[[Category: Cysteine protease]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: zymogen activation]]
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[[Category: Zymogen activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:36:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:24:44 2008''
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Revision as of 17:36, 4 May 2008

Image:3bb7.gif

Template:STRUCTURE 3bb7

Structure of Prevotella intermedia prointerpain A fragment 39-359 (mutant C154A)


Overview

Prevotella intermedia is a major periodontopathogen contributing to human gingivitis and periodontitis. Such pathogens release proteases as virulence factors that cause deterrence of host defenses and tissue destruction. A new cysteine protease from the cysteine-histidine-dyad class, interpain A, was studied in its zymogenic and self-processed mature forms. The latter consists of a bivalved moiety made up by two subdomains. In the structure of a catalytic cysteine-to-alanine zymogen variant, the right subdomain interacts with an unusual prodomain, thus contributing to latency. Unlike the catalytic cysteine residue, already in its competent conformation in the zymogen, the catalytic histidine is swung out from its active conformation and trapped in a cage shaped by a backing helix, a zymogenic hairpin, and a latency flap in the zymogen. Dramatic rearrangement of up to 20A of these elements triggered by a tryptophan switch occurs during activation and accounts for a new activation mechanism for proteolytic enzymes. These findings can be extrapolated to related potentially pathogenic cysteine proteases such as Streprococcus pyogenes SpeB and Porphyromonas gingivalis periodontain.

About this Structure

3BB7 is a Single protein structure of sequence from Prevotella intermedia. Full crystallographic information is available from OCA.

Reference

A New Autocatalytic Activation Mechanism for Cysteine Proteases Revealed by Prevotella intermedia Interpain A., Mallorqui-Fernandez N, Manandhar SP, Mallorqui-Fernandez G, Uson I, Wawrzonek K, Kantyka T, Sola M, Thogersen IB, Enghild JJ, Potempa J, Gomis-Ruth FX, J Biol Chem. 2008 Feb 1;283(5):2871-82. Epub 2007 Nov 9. PMID:17993455 Page seeded by OCA on Sun May 4 20:36:03 2008

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