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3bes
From Proteopedia
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'''Structure of a Poxvirus ifngbp/ifng Complex''' | '''Structure of a Poxvirus ifngbp/ifng Complex''' | ||
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[[Category: Nuara, A A]] | [[Category: Nuara, A A]] | ||
[[Category: Walter, M R.]] | [[Category: Walter, M R.]] | ||
| - | [[Category: | + | [[Category: Antiviral defense]] |
| - | [[Category: | + | [[Category: Cytokine]] |
| - | [[Category: | + | [[Category: Ectromelia virus]] |
| - | [[Category: | + | [[Category: Glycoprotein]] |
| - | [[Category: | + | [[Category: Immune system]] |
| - | [[Category: | + | [[Category: Interferon]] |
| - | [[Category: | + | [[Category: Orthopoxvirus]] |
| - | [[Category: | + | [[Category: Protein complex]] |
| - | [[Category: | + | [[Category: Receptor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:41:44 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:41, 4 May 2008
Structure of a Poxvirus ifngbp/ifng Complex
Contents |
Overview
Ectromelia virus (ECTV) encodes an IFN-gamma-binding protein (IFN-gammaBP(ECTV)) that disrupts IFN-gamma signaling and its ability to induce an antiviral state within cells. IFN-gammaBP(ECTV) is an important virulence factor that is highly conserved (>90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox. The 2.2-A crystal structure of the IFN-gammaBP(ECTV)/IFN-gamma complex reveals IFN-gammaBP(ECTV) consists of an IFN-gammaR1 ligand-binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcription factor TFIIA. The HTH motif forms a tetramerization domain that results in an IFN-gammaBP(ECTV)/IFN-gamma complex containing four IFN-gammaBP(ECTV) chains and two IFN-gamma dimers. The structure, combined with biochemical and cell-based assays, demonstrates that IFN-gammaBP(ECTV) tetramers are required for efficient IFN-gamma antagonism.
Disease
Known disease associated with this structure: AIDS, rapid progression to OMIM:[147570], Aplastic anemia OMIM:[147570], Interferon, immune, deficiency OMIM:[147570], Hepatitis C virus, resistance to OMIM:[147570], TSC2 angiomyolipomas, renal, modifier of OMIM:[147570], Tuberculosis, susceptibility to OMIM:[147570]
About this Structure
3BES is a Protein complex structure of sequences from Ectromelia virus and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein., Nuara AA, Walter LJ, Logsdon NJ, Yoon SI, Jones BC, Schriewer JM, Buller RM, Walter MR, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1861-6. Epub 2008 Feb 5. PMID:18252829 Page seeded by OCA on Sun May 4 20:41:44 2008
