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3hnh

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==Crystal Structure of PqqC Active Site Mutant Y175S,R179S in complex with a reaction intermediate==
==Crystal Structure of PqqC Active Site Mutant Y175S,R179S in complex with a reaction intermediate==
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<StructureSection load='3hnh' size='340' side='right' caption='[[3hnh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3hnh' size='340' side='right'caption='[[3hnh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hnh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Klep7 Klep7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HNH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hnh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klep7 Klep7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HNH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHQ:(2S,7R,9R)-4,5-DIHYDROXY-2,3,6,7,8,9-HEXAHYDRO-1H-PYRROLO[2,3-F]QUINOLINE-2,7,9-TRICARBOXYLIC+ACID'>AHQ</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHQ:(2S,7R,9R)-4,5-DIHYDROXY-2,3,6,7,8,9-HEXAHYDRO-1H-PYRROLO[2,3-F]QUINOLINE-2,7,9-TRICARBOXYLIC+ACID'>AHQ</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1otw|1otw]], [[1otv|1otv]], [[3hlx|3hlx]], [[3hml|3hml]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1otw|1otw]], [[1otv|1otv]], [[3hlx|3hlx]], [[3hml|3hml]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PqqC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272620 KLEP7])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PqqC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272620 KLEP7])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyrroloquinoline-quinone_synthase Pyrroloquinoline-quinone synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.11 1.3.3.11] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyrroloquinoline-quinone_synthase Pyrroloquinoline-quinone synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.11 1.3.3.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hnh OCA], [http://pdbe.org/3hnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hnh RCSB], [http://www.ebi.ac.uk/pdbsum/3hnh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hnh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hnh OCA], [https://pdbe.org/3hnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hnh RCSB], [https://www.ebi.ac.uk/pdbsum/3hnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hnh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PQQC_KLEP7 PQQC_KLEP7]] Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.[HAMAP-Rule:MF_00654]
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[[https://www.uniprot.org/uniprot/PQQC_KLEP7 PQQC_KLEP7]] Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.[HAMAP-Rule:MF_00654]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Klep7]]
[[Category: Klep7]]
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[[Category: Large Structures]]
[[Category: Pyrroloquinoline-quinone synthase]]
[[Category: Pyrroloquinoline-quinone synthase]]
[[Category: Puehringer, S]]
[[Category: Puehringer, S]]

Revision as of 12:53, 23 March 2022

Crystal Structure of PqqC Active Site Mutant Y175S,R179S in complex with a reaction intermediate

PDB ID 3hnh

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