Acetyl-CoA synthetase

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*<scene name='49/492048/Cv/7'>AMP binding site</scene>.
*<scene name='49/492048/Cv/7'>AMP binding site</scene>.
*<scene name='49/492048/Cv/8'>CoA/AMP binding site</scene> ([[2p2j]]).<ref>PMID:17497934</ref>
*<scene name='49/492048/Cv/8'>CoA/AMP binding site</scene> ([[2p2j]]).<ref>PMID:17497934</ref>
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 +
==3D structures of acetyl-CoA synthetase==
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[[Acetyl-CoA synthetase 3D structures]]
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</StructureSection>
</StructureSection>
==3D structures of acetyl-CoA synthetase==
==3D structures of acetyl-CoA synthetase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
- 
[[1pg3]], [[1pg4]] – SeACS (mutant) + CoA + AMP – ''Salmonella enterica''<br />
[[1pg3]], [[1pg4]] – SeACS (mutant) + CoA + AMP – ''Salmonella enterica''<br />
Line 29: Line 32:
[[5k8f]] - CnACS + ATP + acetyl-AMP <br />
[[5k8f]] - CnACS + ATP + acetyl-AMP <br />
[[5ifi]] - CnACS + APP <br />
[[5ifi]] - CnACS + APP <br />
 +
[[5vpv]] - CnACS + acetyl-lysine <br />
 +
[[5u29]] - CnACS + adenosine derivative <br />
[[4xyl]], [[5hbr]] - KcACS + CoA - ''Korarchaeum cryptofilum''<br />
[[4xyl]], [[5hbr]] - KcACS + CoA - ''Korarchaeum cryptofilum''<br />
[[4xym]] - KcACS + AMPCP + CoA <br />
[[4xym]] - KcACS + AMPCP + CoA <br />
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[[4yaj]] - KcACS <br />
[[4yaj]] - KcACS <br />
[[4yak]] - KcACS + CoA + acetyl-CoA <br />
[[4yak]] - KcACS + CoA + acetyl-CoA <br />
 +
[[5u2a]] - ACS – ''Brucella canis'' <br />
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[[6eqo]] - ACS + ATP derivative + NADP - ''Erythrobacter''<br />
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:35, 25 February 2019

Acetyl-CoA synthetase complex with CoA and AMP (PDB code 2p2j)

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3D structures of acetyl-CoA synthetase

Updated on 25-February-2019

1pg3, 1pg4 – SeACS (mutant) + CoA + AMP – Salmonella enterica
2p20, 2p2m, 2p2q - StACS (mutant) + AMP – Salmonella typhimurium
2p2b, 2p2j - StACS (mutant) + CoA + AMP
2p2f, 5jrh - StACS + CoA + AMP
1ry2 – ACS + AMP - yeast
4u5y – ACS GNAT domain + SeACS C terminal (mutant) – Streptomyces lividans
5k85 - CnACS + APP + CoA - Cryptococcus neoformans
5k8f - CnACS + ATP + acetyl-AMP
5ifi - CnACS + APP
5vpv - CnACS + acetyl-lysine
5u29 - CnACS + adenosine derivative
4xyl, 5hbr - KcACS + CoA - Korarchaeum cryptofilum
4xym - KcACS + AMPCP + CoA
4xz3 - KcACS + AMPPCP + CoA
4y8v, 4yb8, 4ybz - KcACS + ADP
4yaj - KcACS
4yak - KcACS + CoA + acetyl-CoA
5u2a - ACS – Brucella canis
6eqo - ACS + ATP derivative + NADP - Erythrobacter

References

  1. Jogl G, Tong L. Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP. Biochemistry. 2004 Feb 17;43(6):1425-31. PMID:14769018 doi:10.1021/bi035911a
  2. Reger AS, Carney JM, Gulick AM. Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase. Biochemistry. 2007 Jun 5;46(22):6536-46. Epub 2007 May 12. PMID:17497934 doi:http://dx.doi.org/10.1021/bi6026506

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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