Charged multivesicular body protein

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'''Charged multivesicular body protein''' (CHMP)s are part of '''E'''ndosomal '''S'''orting '''C'''omplex '''R'''equired for '''T'''ransport ('''ESCRT''') together with the [[Vacuolar protein sorting-associated protein]]s that performs the topologically unique membrane bending and scission reaction away from the cytoplasm. This process is required for the multivesicular body (MVP) pathway, cytokinesis and HIV budding. There are five distinct ESCRT complexes (0,I,II,III,Vps4) with distinct functions<ref>PMID:22361144</ref>. CHMPs are part of the ESCRT-III complex.
'''Charged multivesicular body protein''' (CHMP)s are part of '''E'''ndosomal '''S'''orting '''C'''omplex '''R'''equired for '''T'''ransport ('''ESCRT''') together with the [[Vacuolar protein sorting-associated protein]]s that performs the topologically unique membrane bending and scission reaction away from the cytoplasm. This process is required for the multivesicular body (MVP) pathway, cytokinesis and HIV budding. There are five distinct ESCRT complexes (0,I,II,III,Vps4) with distinct functions<ref>PMID:22361144</ref>. CHMPs are part of the ESCRT-III complex.
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*'''CHMP1A''' and '''CHMP2B''' are part of the ESCRT-III complex. They are required for bodies containing plastid material during autophagy into the cytoplasm <ref>PMID:25649438</ref>.<br />
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*'''CHMP1A''' and '''CHMP2B''' are required for bodies containing plastid material during autophagy into the cytoplasm <ref>PMID:25649438</ref>.<br />
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*'''CHMP2B''' is part of the ESCRT-III complex. Its polimerization scaffolds membranes as part of outward membrane deformation<ref>PMID:21926173</ref>.<br />
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*'''CHMP2B''' polimerization scaffolds membranes as part of outward membrane deformation<ref>PMID:21926173</ref>.<br />
*'''CHMP4B''' circular filament arrays can promote or stabilize negative membrane curvature and outward budding.
*'''CHMP4B''' circular filament arrays can promote or stabilize negative membrane curvature and outward budding.
*'''CHMP5''' has possibly a regulatory role on apoptosis-associated genes.
*'''CHMP5''' has possibly a regulatory role on apoptosis-associated genes.

Revision as of 10:25, 18 December 2018

Caption for this structure

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3D structures of charged multivesicular body protein

Updated on 18-December-2018 {{#tree:id=OrganizedByTopic|openlevels=0|

  • CHMP1B
    • 4txq – hCHMP1B MIM domain + hVps Vta1 N-terminal - human
    • 4txr – hCHMP1B MIM domain + hVps Vta1 N-terminal + CHMP5
    • 6e8g, 3jc1 – hCHMP1B + IST1 + DNA – Cryo EM
    • 2xze – hCHMP1B C-terminal + STAM-binding protein
  • CHMP3
  • CHMP4A
    • 5mk1, 5mk2 – hCHMP4A + tyrosine phosphatase
  • CHMP4B
    • 4abm – hCHMP4B hairpin
    • 3um3 – hCHMP4B C-terminal + BROX
  • CHMP4C
    • 5mk3 – hCHMP4C + tyrosine phosphatase
  • CHMP5
    • 2lxm – hCHMP5 residues 139-195 + hVps Vta1 N-terminal
    • 3uly, 3um0, 3um1, 3um2 – hCHMP5 C-terminal + BROX


References

  1. ↑ Schmidt O, Teis D. The ESCRT machinery. Curr Biol. 2012 Feb 21;22(4):R116-20. doi: 10.1016/j.cub.2012.01.028. PMID:22361144 doi:http://dx.doi.org/10.1016/j.cub.2012.01.028
  2. ↑ Spitzer C, Li F, Buono R, Roschzttardtz H, Chung T, Zhang M, Osteryoung KW, Vierstra RD, Otegui MS. The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis. Plant Cell. 2015 Feb;27(2):391-402. doi: 10.1105/tpc.114.135939. Epub 2015 Feb 3. PMID:25649438 doi:http://dx.doi.org/10.1105/tpc.114.135939
  3. ↑ Bodon G, Chassefeyre R, Pernet-Gallay K, Martinelli N, Effantin G, Hulsik DL, Belly A, Goldberg Y, Chatellard-Causse C, Blot B, Schoehn G, Weissenhorn W, Sadoul R. Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane. J Biol Chem. 2011 Nov 18;286(46):40276-86. doi: 10.1074/jbc.M111.283671. Epub, 2011 Sep 16. PMID:21926173 doi:http://dx.doi.org/10.1074/jbc.M111.283671
  4. ↑ Parkinson N, Ince PG, Smith MO, Highley R, Skibinski G, Andersen PM, Morrison KE, Pall HS, Hardiman O, Collinge J, Shaw PJ, Fisher EM. ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). Neurology. 2006 Sep 26;67(6):1074-7. Epub 2006 Jun 28. PMID:16807408 doi:10.1212/01.wnl.0000231510.89311.8b

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Michal Harel, Alexander Berchansky

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