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6isc

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'''Unreleased structure'''
 
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The entry 6isc is ON HOLD until Paper Publication
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==complex structure of mCD226-ecto and hCD155-D1==
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<StructureSection load='6isc' size='340' side='right' caption='[[6isc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6isc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ISC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ISC FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6isc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6isc OCA], [http://pdbe.org/6isc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6isc RCSB], [http://www.ebi.ac.uk/pdbsum/6isc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6isc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CD226_MOUSE CD226_MOUSE]] Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.[UniProtKB:Q15762] [[http://www.uniprot.org/uniprot/PVR_HUMAN PVR_HUMAN]] Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.<ref>PMID:15471548</ref> <ref>PMID:15607800</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gao, G F]]
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[[Category: Li, Y]]
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[[Category: Qi, J]]
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[[Category: Tan, S]]
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[[Category: Wang, H]]
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[[Category: Zhang, S]]
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[[Category: Cd155]]
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[[Category: Complex structure]]
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[[Category: Immune system]]
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[[Category: Mcd226]]
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[[Category: Nk cell receptor]]

Revision as of 08:25, 26 December 2018

complex structure of mCD226-ecto and hCD155-D1

6isc, resolution 2.20Å

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