3bmz

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[[Image:3bmz.jpg|left|200px]]
[[Image:3bmz.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3bmz |SIZE=350|CAPTION= <scene name='initialview01'>3bmz</scene>, resolution 1.21&Aring;
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The line below this paragraph, containing "STRUCTURE_3bmz", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Pg4+Binding+Site+For+Residue+A+901'>AC1</scene> and <scene name='pdbsite=AC2:Pge+Binding+Site+For+Residue+B+902'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= VioE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=536 Chromobacterium violaceum])
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-->
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|DOMAIN=
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{{STRUCTURE_3bmz| PDB=3bmz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bmz OCA], [http://www.ebi.ac.uk/pdbsum/3bmz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bmz RCSB]</span>
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}}
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'''Violacein biosynthetic enzyme VioE'''
'''Violacein biosynthetic enzyme VioE'''
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[[Category: Drennan, C L.]]
[[Category: Drennan, C L.]]
[[Category: Ryan, K S.]]
[[Category: Ryan, K S.]]
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[[Category: biosynthetic protein]]
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[[Category: Biosynthetic protein]]
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[[Category: violacein]]
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[[Category: Violacein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:55:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:27:32 2008''
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Revision as of 17:55, 4 May 2008

Template:STRUCTURE 3bmz

Violacein biosynthetic enzyme VioE


Overview

VioE, an unusual enzyme with no characterized homologues, plays a key role in the biosynthesis of violacein, a purple pigment with antibacterial and cytotoxic properties. Without bound cofactors or metals, VioE, from the bacterium Chromobacterium violaceum, mediates a 1,2 shift of an indole ring and oxidative chemistry to generate prodeoxyviolacein, a precursor to violacein. Our 1.21 A resolution structure of VioE shows that the enzyme shares a core fold previously described for lipoprotein transporter proteins LolA and LolB. For both LolB and VioE, a bound polyethylene glycol molecule suggests the location of the binding and/or active site of the protein. Mutations of residues near the bound polyethylene glycol molecule in VioE have identified the active site and five residues important for binding or catalysis. This structural and mutagenesis study suggests that VioE acts as a catalytic chaperone, using a fold previously associated with lipoprotein transporters to catalyze the production of its prodeoxyviolacein product.

About this Structure

3BMZ is a Single protein structure of sequence from Chromobacterium violaceum. Full crystallographic information is available from OCA.

Reference

The Violacein Biosynthetic Enzyme VioE Shares a Fold with Lipoprotein Transporter Proteins., Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL, J Biol Chem. 2008 Mar 7;283(10):6467-75. Epub 2008 Jan 2. PMID:18171675 Page seeded by OCA on Sun May 4 20:55:12 2008

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