6nbf

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m (Protected "6nbf" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6nbf is ON HOLD until Paper Publication
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==Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein==
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<StructureSection load='6nbf' size='340' side='right'caption='[[6nbf]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nbf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NBF FirstGlance]. <br>
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Description: Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbf OCA], [http://pdbe.org/6nbf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nbf RCSB], [http://www.ebi.ac.uk/pdbsum/6nbf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbf ProSAT]</span></td></tr>
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[[Category: Zhou, X.E]]
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</table>
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[[Category: Xu, H.E]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] Blomstrand lethal chondrodysplasia;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/GBB1_RAT GBB1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref> [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Clark, L J]]
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[[Category: Gardella, T J]]
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[[Category: Jean-Alphonse, F G]]
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[[Category: Jiang, Y]]
[[Category: Kang, Y]]
[[Category: Kang, Y]]
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[[Category: Vilardaga, J.-P]]
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[[Category: Li, C Y]]
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[[Category: Ma, S]]
[[Category: Melcher, K]]
[[Category: Melcher, K]]
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[[Category: Jean-Alphonse, F.G]]
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[[Category: Shen, D D]]
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[[Category: Sutkeviciute, I]]
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[[Category: Vilardaga, J P]]
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[[Category: Waal, P P.de]]
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[[Category: Wang, M W]]
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[[Category: Watanabe, T]]
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[[Category: White, A D]]
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[[Category: Xiao, K]]
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[[Category: Xu, H E]]
[[Category: Yang, D]]
[[Category: Yang, D]]
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[[Category: White, A.D]]
 
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[[Category: Li, C.-Y]]
 
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[[Category: Gardella, T.J]]
 
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[[Category: Jiang, Y]]
 
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[[Category: De Waal, P.P]]
 
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[[Category: Ma, S]]
 
[[Category: Zhang, Y]]
[[Category: Zhang, Y]]
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[[Category: Sutkeviciute, I]]
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[[Category: Zhao, L H]]
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[[Category: Zhao, L.-H]]
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[[Category: Zhou, X E]]
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[[Category: Clark, L.J]]
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[[Category: Class b gpcr]]
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[[Category: Xiao, K]]
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[[Category: Gpcr]]
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[[Category: Wang, M.-W]]
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[[Category: Gpcr-g protein complex]]
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[[Category: Shen, D.-D]]
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[[Category: Parathyroid hormone receptor]]
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[[Category: Watanabe, T]]
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[[Category: Signaling protein]]

Revision as of 06:03, 17 April 2019

Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein

PDB ID 6nbf

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