6nda

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m (Protected "6nda" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6nda is ON HOLD
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==RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM==
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<StructureSection load='6nda' size='340' side='right' caption='[[6nda]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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Authors: Stetefeld, J., McDougall, M.D., Loewen, P.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nda]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NDA FirstGlance]. <br>
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Description: RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nda OCA], [http://pdbe.org/6nda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nda RCSB], [http://www.ebi.ac.uk/pdbsum/6nda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nda ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SLEC_CALRH SLEC_CALRH]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref> [[http://www.uniprot.org/uniprot/ITA2_HUMAN ITA2_HUMAN]] Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. [[http://www.uniprot.org/uniprot/SLED_CALRH SLED_CALRH]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Calloselasma rhodostoma]]
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[[Category: Loewen, P C]]
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[[Category: McDougall, M D]]
[[Category: Stetefeld, J]]
[[Category: Stetefeld, J]]
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[[Category: Loewen, P.C]]
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[[Category: C-type lectin]]
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[[Category: Mcdougall, M.D]]
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[[Category: Cadmium]]
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[[Category: Cell adhesion]]
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[[Category: Cell adhesion-toxin complex]]
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[[Category: Coagulation]]
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[[Category: Integrin]]
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[[Category: Venom]]

Revision as of 08:27, 26 December 2018

RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM

6nda, resolution 3.15Å

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