3brw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:3brw.jpg|left|200px]]
[[Image:3brw.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 3brw |SIZE=350|CAPTION= <scene name='initialview01'>3brw</scene>, resolution 3.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_3brw", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+D+172'>AC1</scene>, <scene name='pdbsite=AC2:Bef+Binding+Site+For+Residue+D+170'>AC2</scene> and <scene name='pdbsite=AC3:Gdp+Binding+Site+For+Residue+D+171'>AC3</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= RAP1GAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RAP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_3brw| PDB=3brw | SCENE= }}
-
|RELATEDENTRY=[[1srq|1SRQ]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3brw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3brw OCA], [http://www.ebi.ac.uk/pdbsum/3brw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3brw RCSB]</span>
+
-
}}
+
'''Structure of the Rap-RapGAP complex'''
'''Structure of the Rap-RapGAP complex'''
Line 29: Line 26:
[[Category: Thomas, C.]]
[[Category: Thomas, C.]]
[[Category: Wittinghofer, A.]]
[[Category: Wittinghofer, A.]]
-
[[Category: g protein]]
+
[[Category: G protein]]
-
[[Category: gap]]
+
[[Category: Gap]]
-
[[Category: gtp binding protein]]
+
[[Category: Gtp binding protein]]
-
[[Category: gtp-binding]]
+
[[Category: Gtp-binding]]
-
[[Category: gtpase]]
+
[[Category: Gtpase]]
-
[[Category: gtpase activation]]
+
[[Category: Gtpase activation]]
-
[[Category: rap]]
+
[[Category: Rap]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:33:36 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:28:32 2008''
+

Revision as of 06:33, 24 April 2008

Image:3brw.jpg

Template:STRUCTURE 3brw

Structure of the Rap-RapGAP complex


Overview

The GTP-binding protein Rap1 regulates integrin-mediated and other cell adhesion processes. Unlike most other Ras-related proteins, it contains a threonine in switch II instead of a glutamine (Gln61 in Ras), a residue crucial for the GTPase reaction of most G proteins. Furthermore, unlike most other GTPase-activating proteins (GAPs) for small G proteins, which supply a catalytically important Arg-finger, no arginine residue of RapGAP makes a significant contribution to the GTPase reaction of Rap1. For a detailed understanding of the reaction mechanism, we have solved the structure of Rap1 in complex with Rap1GAP. It shows that the Thr61 of Rap is away from the active site and that an invariant asparagine of RapGAPs, the Asn-thumb, takes over the role of the cis-glutamine of Ras, Rho or Ran. The structure and biochemical data allow to further explain the mechanism and to define the important role of a conserved tyrosine. The structure and biochemical data furthermore show that the RapGAP homologous region of the tumour suppressor Tuberin is sufficient for catalysis on Rheb.

About this Structure

3BRW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues., Scrima A, Thomas C, Deaconescu D, Wittinghofer A, EMBO J. 2008 Feb 28;. PMID:18309292 Page seeded by OCA on Thu Apr 24 09:33:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3brw"
Personal tools