3buy

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[[Image:3buy.jpg|left|200px]]
[[Image:3buy.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3buy |SIZE=350|CAPTION= <scene name='initialview01'>3buy</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_3buy", creates the "Structure Box" on the page.
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|SITE=
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|GENE= H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), PB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 Influenza A virus])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00098 IGc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00129 MHC_I]</span>
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{{STRUCTURE_3buy| PDB=3buy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3buy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3buy OCA], [http://www.ebi.ac.uk/pdbsum/3buy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3buy RCSB]</span>
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'''MHC-I in complex with peptide'''
'''MHC-I in complex with peptide'''
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[[Category: Rossjohn, J.]]
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[[Category: Turner, S J.]]
[[Category: Turner, S J.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:08:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:29:15 2008''
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Revision as of 18:08, 4 May 2008

Image:3buy.jpg

Template:STRUCTURE 3buy

MHC-I in complex with peptide


Overview

TCR repertoire diversity has been convincingly shown to facilitate responsiveness of CD8+ T cell populations to mutant virus peptides, thereby safeguarding against viral escape. However, the impact of repertoire diversity on the functionality of the CD8+ T cell response to cognate peptide-MHC class I complex (pMHC) recognition remains unclear. Here, we have compared TCRbeta chain repertoires of three influenza A epitope-specific CD8+ T cell responses in C57BL/6 (B6) mice: D(b)NP(366-374), D(b)PA(224-233), and a recently described epitope derived from the +1 reading frame of the influenza viral polymerase B subunit (residues 62-70) (D(b)PB1-F2(62)). Corresponding to the relative antigenicity of the respective pMHCs, and irrespective of the location of prominent residues, the D(b)PA(224)- and D(b)PB1-F2(62)-specific repertoires were similarly diverse, whereas the D(b)NP(366) population was substantially narrower. Importantly, parallel analysis of response magnitude, cytotoxicity, TCR avidity, and cytokine production for the three epitope-specific responses revealed no obvious functional advantage conferred by increased T cell repertoire diversity. Thus, whereas a diverse repertoire may be important for recognition of epitope variants, its effect on the response to cognate pMHC recognition appears minimal.

About this Structure

3BUY is a Protein complex structure of sequences from Influenza a virus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides., La Gruta NL, Thomas PG, Webb AI, Dunstone MA, Cukalac T, Doherty PC, Purcell AW, Rossjohn J, Turner SJ, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2034-9. Epub 2008 Jan 31. PMID:18238896 Page seeded by OCA on Sun May 4 21:08:17 2008

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