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6hg2

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Current revision (10:25, 15 November 2023) (edit) (undo)
 
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==Hybrid dihydroorotase domain of human CAD with E. coli flexible loop, bound to fluoroorotate==
==Hybrid dihydroorotase domain of human CAD with E. coli flexible loop, bound to fluoroorotate==
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<StructureSection load='6hg2' size='340' side='right' caption='[[6hg2]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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<StructureSection load='6hg2' size='340' side='right'caption='[[6hg2]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hg2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HG2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hg2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HG2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=FOT:5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>FOT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=FOT:5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>FOT</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hg2 OCA], [https://pdbe.org/6hg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hg2 RCSB], [https://www.ebi.ac.uk/pdbsum/6hg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hg2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hg2 OCA], [http://pdbe.org/6hg2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hg2 RCSB], [http://www.ebi.ac.uk/pdbsum/6hg2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hg2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PYR1_HUMAN PYR1_HUMAN]] This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
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[https://www.uniprot.org/uniprot/PYR1_HUMAN PYR1_HUMAN] This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hg2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hg2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CAD protein 3D structures|CAD protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cano-Ochoa, F Del]]
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[[Category: Large Structures]]
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[[Category: Ramon-Maiques, S]]
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[[Category: Del Cano-Ochoa F]]
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[[Category: Biosynthetic protein]]
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[[Category: Ramon-Maiques S]]
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[[Category: Cad]]
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[[Category: Carboxylated lysine]]
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[[Category: De novo pyrimidine biosynthesis]]
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[[Category: Tim-barrel]]
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Current revision

Hybrid dihydroorotase domain of human CAD with E. coli flexible loop, bound to fluoroorotate

PDB ID 6hg2

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