3i9t
From Proteopedia
(Difference between revisions)
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==Crystal structure of the rat heme oxygenase (HO-1) in complex with heme binding dithiothreitol (DTT)== | ==Crystal structure of the rat heme oxygenase (HO-1) in complex with heme binding dithiothreitol (DTT)== | ||
- | <StructureSection load='3i9t' size='340' side='right' caption='[[3i9t]], [[Resolution|resolution]] 2.15Å' scene=''> | + | <StructureSection load='3i9t' size='340' side='right'caption='[[3i9t]], [[Resolution|resolution]] 2.15Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3i9t]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3i9t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I9T FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> |
- | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ivj|1ivj]], [[3i8r|3i8r]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ivj|1ivj]], [[3i8r|3i8r]]</div></td></tr> |
- | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hmox1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hmox1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> |
- | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Heme_oxygenase Heme oxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.3 1.14.99.3] </span></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9t OCA], [https://pdbe.org/3i9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i9t RCSB], [https://www.ebi.ac.uk/pdbsum/3i9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i9t ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/HMOX1_RAT HMOX1_RAT]] Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
- | *[[Heme oxygenase|Heme oxygenase]] | + | *[[Heme oxygenase 3D structures|Heme oxygenase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Buffalo rat]] | [[Category: Buffalo rat]] | ||
[[Category: Heme oxygenase]] | [[Category: Heme oxygenase]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Ikeda-Saito, M]] | [[Category: Ikeda-Saito, M]] | ||
[[Category: Matsui, T]] | [[Category: Matsui, T]] |
Revision as of 11:01, 13 April 2022
Crystal structure of the rat heme oxygenase (HO-1) in complex with heme binding dithiothreitol (DTT)
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Categories: Buffalo rat | Heme oxygenase | Large Structures | Ikeda-Saito, M | Matsui, T | Unno, M | Endoplasmic reticulum | Heme | Inhibitor | Iron | Isozyme | Mammalian | Metal-binding | Microsome | Oxidoreductase | Phosphoprotein