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3c0o

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[[Image:3c0o.jpg|left|200px]]
[[Image:3c0o.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3c0o |SIZE=350|CAPTION= <scene name='initialview01'>3c0o</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_3c0o", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Act+Binding+Site+For+Residue+A+600'>AC1</scene>, <scene name='pdbsite=AC2:M6p+Binding+Site+For+Residue+A+501'>AC2</scene> and <scene name='pdbsite=AC3:M6p+Binding+Site+For+Residue+B+502'>AC3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=M6P:ALPHA-D-MANNOSE-6-PHOSPHATE'>M6P</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= aerA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 Aeromonas hydrophila])
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-->
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|DOMAIN=
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{{STRUCTURE_3c0o| PDB=3c0o | SCENE= }}
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|RELATEDENTRY=[[3c0m|3C0M]], [[3c0n|3C0N]], [[1pre|1PRE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c0o OCA], [http://www.ebi.ac.uk/pdbsum/3c0o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3c0o RCSB]</span>
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}}
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'''Crystal structure of the proaerolysin mutant Y221G complexed with mannose-6-phosphate'''
'''Crystal structure of the proaerolysin mutant Y221G complexed with mannose-6-phosphate'''
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[[Category: Schiltz, M.]]
[[Category: Schiltz, M.]]
[[Category: Thurnheer, S.]]
[[Category: Thurnheer, S.]]
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[[Category: cytolytic toxin]]
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[[Category: Cytolytic toxin]]
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[[Category: pore-forming toxin]]
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[[Category: Pore-forming toxin]]
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[[Category: toxin]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:16:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:29:59 2008''
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Revision as of 18:16, 4 May 2008

Image:3c0o.jpg

Template:STRUCTURE 3c0o

Crystal structure of the proaerolysin mutant Y221G complexed with mannose-6-phosphate


Overview

Aerolysin is chiefly responsible for the pathogenicity of Aeromonas hydrophila, a bacterium associated with diarrhoeal diseases and deep wound infections. Like many other microbial toxins, the protein changes in a multistep process from a completely water-soluble form to produce a transmembrane channel that destroys sensitive cells by breaking their permeability barriers. Here we describe the structure of proaerolysin determined by X-ray crystallography at 2.8 A resolution. The protoxin (M(r) 52,000) adopts a novel protein fold. Images of an aerolysin oligomer derived from electron microscopy have assisted in constructing a model of the membrane channel and have led to the proposal of a scheme to account for insertion of the protein into lipid bilayers to form ion channels.

About this Structure

3C0O is a Single protein structure of sequence from Aeromonas hydrophila. Full crystallographic information is available from OCA.

Reference

Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states., Parker MW, Buckley JT, Postma JP, Tucker AD, Leonard K, Pattus F, Tsernoglou D, Nature. 1994 Jan 20;367(6460):292-5. PMID:7510043 Page seeded by OCA on Sun May 4 21:16:06 2008

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