6akk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the second Coiled-coil domain of SIKE1== | |
| - | + | <StructureSection load='6akk' size='340' side='right' caption='[[6akk]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6akk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AKK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6akk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6akk OCA], [http://pdbe.org/6akk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6akk RCSB], [http://www.ebi.ac.uk/pdbsum/6akk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6akk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIKE1_HUMAN SIKE1_HUMAN]] Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.<ref>PMID:16281057</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chen, M]] | ||
| + | [[Category: Zhou, L]] | ||
| + | [[Category: Zhou, Z C]] | ||
| + | [[Category: Coiled-coil]] | ||
| + | [[Category: Homotetramer]] | ||
| + | [[Category: Protein binding]] | ||
Revision as of 12:00, 16 January 2019
Crystal structure of the second Coiled-coil domain of SIKE1
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