This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6irc
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==C-terminal domain of Drosophila phospholipase b NORPA, methylated== | |
| - | + | <StructureSection load='6irc' size='340' side='right' caption='[[6irc]], [[Resolution|resolution]] 3.54Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6irc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IRC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irc OCA], [http://pdbe.org/6irc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irc RCSB], [http://www.ebi.ac.uk/pdbsum/6irc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irc ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Phosphoinositide phospholipase C]] | ||
| + | [[Category: Huang, Y]] | ||
| + | [[Category: Li, J]] | ||
[[Category: Liu, W]] | [[Category: Liu, W]] | ||
[[Category: Ye, F]] | [[Category: Ye, F]] | ||
| - | [[Category: | + | [[Category: Zhang, M]] |
| - | [[Category: | + | [[Category: Coiled coil]] |
| + | [[Category: Drosophila]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Phospholipase beta]] | ||
Revision as of 06:12, 2 January 2019
C-terminal domain of Drosophila phospholipase b NORPA, methylated
| |||||||||||
