3crd
From Proteopedia
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'''NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES''' | '''NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES''' | ||
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[[Category: Matsuo, H.]] | [[Category: Matsuo, H.]] | ||
[[Category: Wagner, G.]] | [[Category: Wagner, G.]] | ||
| - | [[Category: | + | [[Category: Apoptosis]] |
| - | [[Category: | + | [[Category: Caspase recruitment domain]] |
| - | [[Category: | + | [[Category: Homophilic interaction]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:57:52 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:57, 4 May 2008
NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES
Overview
Apoptosis requires recruitment of caspases by receptor-associated adaptors through homophilic interactions between the CARDs (caspase recruitment domains) of adaptor proteins and prodomains of caspases. We have solved the CARD structure of the RAIDD adaptor protein that recruits ICH-1/caspase-2. It consists of six tightly packed helices arranged in a topology homologous to the Fas death domain. The surface contains a basic and an acidic patch on opposite sides. This polarity is conserved in the ICH-1 CARD as indicated by homology modeling. Mutagenesis data suggest that these patches mediate CARD/CARD interaction between RAIDD and ICH-1. Subsequent modeling of the CARDs of Apaf-1 and caspase-9, as well as Ced-4 and Ced-3, showed that the basic/acidic surface polarity is highly conserved, suggesting a general mode for CARD/CARD interaction.
About this Structure
3CRD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment., Chou JJ, Matsuo H, Duan H, Wagner G, Cell. 1998 Jul 24;94(2):171-80. PMID:9695946 Page seeded by OCA on Sun May 4 21:57:52 2008
