3kcu

<StructureSection load='3kcu' size='340' side='right' caption='[[3kcu]], [[Resolution|resolution]] 2.24&Aring;' scene=''>

<table><tr><td colspan='2'>[[3kcu]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KCU FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MA5:2-(6-(2-CYCLOHEXYLETHOXY)-TETRAHYDRO-4,5-DIHYDROXY-2(HYDROXYMETHYL)-2H-PYRAN-3-YLOXY)-TETRAHYDRO-6(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>MA5</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FOCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kcu OCA], [http://pdbe.org/3kcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kcu RCSB], [http://www.ebi.ac.uk/pdbsum/3kcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kcu ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/FOCA_ECO57 FOCA_ECO57]] Involved in the bidirectional transport of formate (By similarity).

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== Publication Abstract from PubMed ==

FocA is a representative member of the formate-nitrite transporter family, which transports short-chain acids in bacteria, archaea, fungi, algae and parasites. The structure and transport mechanism of the formate-nitrite transporter family remain unknown. Here we report the crystal structure of Escherichia coli FocA at 2.25 A resolution. FocA forms a symmetric pentamer, with each protomer consisting of six transmembrane segments. Despite a lack of sequence homology, the overall structure of the FocA protomer closely resembles that of aquaporin and strongly argues that FocA is a channel, rather than a transporter. Structural analysis identifies potentially important channel residues, defines the channel path and reveals two constriction sites. Unlike aquaporin, FocA is impermeable to water but allows the passage of formate. A structural and biochemical investigation provides mechanistic insights into the channel activity of FocA.

Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel.,Wang Y, Huang Y, Wang J, Cheng C, Huang W, Lu P, Xu YN, Wang P, Yan N, Shi Y Nature. 2009 Nov 26;462(7272):467-72. PMID:19940917<ref>PMID:19940917</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3kcu" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Eco57]]

[[Category: Huang, Y]]

[[Category: Shi, Y]]

[[Category: Wang, J]]

[[Category: Wang, Y]]

[[Category: Yan, N]]

[[Category: Transporter]]