3k2i
From Proteopedia
(Difference between revisions)
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==Human Acyl-coenzyme A thioesterase 4== | ==Human Acyl-coenzyme A thioesterase 4== | ||
| - | <StructureSection load='3k2i' size='340' side='right' caption='[[3k2i]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='3k2i' size='340' side='right'caption='[[3k2i]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3k2i]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3k2i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K2I FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACOT4 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACOT4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k2i OCA], [https://pdbe.org/3k2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k2i RCSB], [https://www.ebi.ac.uk/pdbsum/3k2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k2i ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ACOT4_HUMAN ACOT4_HUMAN]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Thioesterase|Thioesterase]] | + | *[[Thioesterase 3D structures|Thioesterase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Palmitoyl-CoA hydrolase]] | [[Category: Palmitoyl-CoA hydrolase]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
Revision as of 07:49, 10 November 2021
Human Acyl-coenzyme A thioesterase 4
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Categories: Human | Large Structures | Palmitoyl-CoA hydrolase | Arrowsmith, C H | Berg, S Van Den | Berglund, H | Bountra, C | Collins, R | Edwards, A M | Flodin, S | Flores, A | Graslund, S | Hammarstrom, M | Johansson, A | Johansson, I | Kallas, A | Karlberg, T | Kotenyova, T | Kotzsch, A | Kraulis, P | Markova, N | Moche, M | Nielsen, T K | Nordlund, P | Nyman, T | Persson, C | Roos, A K | Structural genomic | Schuler, H | Schutz, P | Siponen, M I | Svensson, L | Thorsell, A G | Tresaugues, L | Wahlberg, E | Weigelt, J | Welin, M | Wisniewska, M | Alpha/beta hydrolase fold seven-stranded beta-sandwich | Hydrolase | Peroxisome | Polymorphism | Serine esterase | Sgc
