Epithelial discoidin domain-containing receptor
From Proteopedia
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== Function == | == Function == | ||
| - | '''Epithelial discoidin domain-containing receptor 1''' (DDR1) | + | '''Epithelial discoidin domain-containing receptor 1''' (DDR1) is an extracellular matrix-sensing receptor [[Tyrosine kinase]] which is activated by collagen and is expressed in bronchial epithelium. It is responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. |
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
| + | DDR1 plays a consequential role in a variety of cancers<ref>PMID:27020590</ref>. | ||
A low DDR1/high DDR2 profile is associated with high tumor grade and may identify invasive carcinomas with worse prognosis<ref>PMID:25667101</ref>. | A low DDR1/high DDR2 profile is associated with high tumor grade and may identify invasive carcinomas with worse prognosis<ref>PMID:25667101</ref>. | ||
Revision as of 07:45, 30 December 2018
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3D structures of epithelial discoidin domain-containing receptor 1
Updated on 30-December-2018
5bvk – hDDR1 kinase domain 564-913 – human
3zos, 4bkj, 4bkj – hDDR1 kinase domain + cancer drug
6few – hDDR1 kinase domain + alport syndrome drug
6fex, 6fil, 6fim, 6fin, 6fio, 6fiq – hDDR1 kinase domain (mutant) + alport syndrome drug
4ckr, 5bvn, 5bvo, 5bvw, 5fdp, 5fdx, 6brj, 6gwr – hDDR1 kinase domain + inhibitor
4ag4 – hDDR1 29-367 domain + antibody
References
- ↑ Roberts ME, Magowan L, Hall IP, Johnson SR. Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production. Eur Respir J. 2011 Jun;37(6):1482-93. doi: 10.1183/09031936.00039710. Epub 2010, Sep 30. PMID:20884741 doi:http://dx.doi.org/10.1183/09031936.00039710
- ↑ Song J, Chen X, Bai J, Liu Q, Li H, Xie J, Jing H, Zheng J. Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumour Biol. 2016 Aug;37(8):11509-21. doi: 10.1007/s13277-016-5021-2. Epub 2016, Mar 28. PMID:27020590 doi:http://dx.doi.org/10.1007/s13277-016-5021-2
- ↑ Toy KA, Valiathan RR, Nunez F, Kidwell KM, Gonzalez ME, Fridman R, Kleer CG. Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer. Breast Cancer Res Treat. 2015 Feb;150(1):9-18. doi: 10.1007/s10549-015-3285-7., Epub 2015 Feb 10. PMID:25667101 doi:http://dx.doi.org/10.1007/s10549-015-3285-7
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