Sandbox 1498
From Proteopedia
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== Function == | == Function == | ||
| - | 3BPU is involved in the cell signalisation. It may play a role as a scaffolding protein at cell-cell junctions. It may | + | 3BPU is involved in the cell signalisation. It may play a role as a scaffolding protein at cell-cell junctions. It may regulate acid-induced ASIC3<ref >http://www.rcsb.org/pdb/protein/Q9UHC3</ref> currents by modulating its expression at the cell surface through interacting with its PDZ domain. |
| + | It may also allow the interaction of Q96QZ7 with JAM4, providing an adhesion machinery at tight junctions. This may regulate the permeability of kidney glomerulus and small intestinal epithelial cells.<ref>https://www.uniprot.org/citations/12773569</ref> | ||
== Structure == | == Structure == | ||
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=== Secondary structure === | === Secondary structure === | ||
3BPU structure is composed of 10% of helix (1 left-handed alpha helix; 9 residues) and 40% of beta sheets (8 antiparallel strands; 36 residues). | 3BPU structure is composed of 10% of helix (1 left-handed alpha helix; 9 residues) and 40% of beta sheets (8 antiparallel strands; 36 residues). | ||
| + | Dire quels acides aminés composent majoritairement les hélices et les brins. | ||
=== Tertiary structure === | === Tertiary structure === | ||
Revision as of 15:25, 29 December 2018
Contents |
3BPU
3BPU is a transferase found in Homo sapiens. It is the 3rd PDZ domain of human membrane associated guanylate kinase Q96QZ7, C677S and C709S double mutant. It is encoded by the MAGI1 gene. [1]
Function
3BPU is involved in the cell signalisation. It may play a role as a scaffolding protein at cell-cell junctions. It may regulate acid-induced ASIC3[1] currents by modulating its expression at the cell surface through interacting with its PDZ domain. It may also allow the interaction of Q96QZ7 with JAM4, providing an adhesion machinery at tight junctions. This may regulate the permeability of kidney glomerulus and small intestinal epithelial cells.[2]
Structure
Primary structure
3BPU is a one chain structure of 88 amino-acids.
Secondary structure
3BPU structure is composed of 10% of helix (1 left-handed alpha helix; 9 residues) and 40% of beta sheets (8 antiparallel strands; 36 residues). Dire quels acides aminés composent majoritairement les hélices et les brins.
Tertiary structure
Protéine membranaire donc acides aminés polaires à l'intérieur de la protéine?
Parler des interactions avec les ions Zn https://www.rcsb.org/3d-view/3BPU?preset=ligandInteraction&sele=ZN
