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Epithelial discoidin domain-containing receptor

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== Function ==
== Function ==
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'''Epithelial discoidin domain-containing receptor 1''' (DDR1) is an extracellular matrix-sensing receptor [[Tyrosine kinase]] which is activated by collagen and is expressed in bronchial epithelium. It is responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>.
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'''Epithelial discoidin domain-containing receptor''' (DDR1 and DDR2) are extracellular matrix-sensing receptors [[Tyrosine kinase]] which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>.
== Disease ==
== Disease ==
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</StructureSection>
</StructureSection>
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==3D structures of epithelial discoidin domain-containing receptor 1==
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==3D structures of epithelial discoidin domain-containing receptor 1*Epithelial discoidin domain-containing receptor 1==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[5bvk]] – hDDR1 kinase domain 564-913 – human<br />
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*Epithelial discoidin domain-containing receptor 1; Domains – discoidin 26-186; ligand-binding 283-385; kinase 543-838
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[[3zos]], [[4bkj]] – hDDR1 kinase domain + cancer drug<br />
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[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />
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**[[5bvk]] – hDDR1 kinase domain 564-913 – human<br />
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[[6fex]], [[6fil]], [[6fim]], [[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />
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**[[3zos]], [[4bkj]] – hDDR1 kinase domain + cancer drug<br />
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[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]] – hDDR1 kinase domain + inhibitor<br />
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**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />
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[[4ag4]] – hDDR1 29-367 domain + antibody<br />
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**[[6fex]], [[6fil]], [[6fim]], [[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />
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**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]] – hDDR1 kinase domain + inhibitor<br />
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**[[4ag4]] – hDDR1 29-367 domain + antibody<br />
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*Epithelial discoidin domain-containing receptor 2
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**[[2z4f]] – hDDR2 discoidin domain – NMR<br />
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**[[2wuh]] – hDDR2 discoidin domain + collagen<br />
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**[[6fer]] – hDDR2 kinase domain + inhibitor<br />
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}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:00, 31 December 2018

Human DDR1 kinase domain complex with imatinib and ethylene glycol (PDB code 4bkj)

Drag the structure with the mouse to rotate

3D structures of epithelial discoidin domain-containing receptor 1*Epithelial discoidin domain-containing receptor 1

Updated on 31-December-2018

References

  1. ↑ Roberts ME, Magowan L, Hall IP, Johnson SR. Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production. Eur Respir J. 2011 Jun;37(6):1482-93. doi: 10.1183/09031936.00039710. Epub 2010, Sep 30. PMID:20884741 doi:http://dx.doi.org/10.1183/09031936.00039710
  2. ↑ 2.0 2.1 Borza CM, Pozzi A. Discoidin domain receptors in disease. Matrix Biol. 2014 Feb;34:185-92. doi: 10.1016/j.matbio.2013.12.002. Epub 2013 Dec, 19. PMID:24361528 doi:http://dx.doi.org/10.1016/j.matbio.2013.12.002
  3. ↑ Song J, Chen X, Bai J, Liu Q, Li H, Xie J, Jing H, Zheng J. Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumour Biol. 2016 Aug;37(8):11509-21. doi: 10.1007/s13277-016-5021-2. Epub 2016, Mar 28. PMID:27020590 doi:http://dx.doi.org/10.1007/s13277-016-5021-2
  4. ↑ Toy KA, Valiathan RR, Nunez F, Kidwell KM, Gonzalez ME, Fridman R, Kleer CG. Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer. Breast Cancer Res Treat. 2015 Feb;150(1):9-18. doi: 10.1007/s10549-015-3285-7., Epub 2015 Feb 10. PMID:25667101 doi:http://dx.doi.org/10.1007/s10549-015-3285-7
  5. ↑ Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN. Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818 doi:http://dx.doi.org/10.1016/j.jmb.2014.04.014

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