Epithelial discoidin domain-containing receptor

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**[[5bvk]] – hDDR1 kinase domain 564-913 – human<br />
**[[5bvk]] – hDDR1 kinase domain 564-913 – human<br />
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**[[3zos]], [[4bkj]] – hDDR1 kinase domain + cancer drug<br />
+
**[[3zos]], [[4bkj]], [[6bsd]] – hDDR1 kinase domain + cancer drug<br />
**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />
**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />
**[[6fex]], [[6fil]], [[6fim]], [[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />
**[[6fex]], [[6fil]], [[6fim]], [[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />
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**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]] – hDDR1 kinase domain + inhibitor<br />
+
**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]], [[6hp9]] – hDDR1 kinase domain + inhibitor<br />
**[[4ag4]] – hDDR1 29-367 domain + antibody<br />
**[[4ag4]] – hDDR1 29-367 domain + antibody<br />

Revision as of 08:26, 23 June 2019

Human DDR1 kinase domain complex with imatinib and ethylene glycol (PDB code 4bkj)

Drag the structure with the mouse to rotate

3D structures of epithelial discoidin domain-containing receptor

Updated on 23-June-2019

References

  1. ↑ Roberts ME, Magowan L, Hall IP, Johnson SR. Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production. Eur Respir J. 2011 Jun;37(6):1482-93. doi: 10.1183/09031936.00039710. Epub 2010, Sep 30. PMID:20884741 doi:http://dx.doi.org/10.1183/09031936.00039710
  2. ↑ 2.0 2.1 Borza CM, Pozzi A. Discoidin domain receptors in disease. Matrix Biol. 2014 Feb;34:185-92. doi: 10.1016/j.matbio.2013.12.002. Epub 2013 Dec, 19. PMID:24361528 doi:http://dx.doi.org/10.1016/j.matbio.2013.12.002
  3. ↑ Song J, Chen X, Bai J, Liu Q, Li H, Xie J, Jing H, Zheng J. Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumour Biol. 2016 Aug;37(8):11509-21. doi: 10.1007/s13277-016-5021-2. Epub 2016, Mar 28. PMID:27020590 doi:http://dx.doi.org/10.1007/s13277-016-5021-2
  4. ↑ Toy KA, Valiathan RR, Nunez F, Kidwell KM, Gonzalez ME, Fridman R, Kleer CG. Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer. Breast Cancer Res Treat. 2015 Feb;150(1):9-18. doi: 10.1007/s10549-015-3285-7., Epub 2015 Feb 10. PMID:25667101 doi:http://dx.doi.org/10.1007/s10549-015-3285-7
  5. ↑ Canning P, Tan L, Chu K, Lee SW, Gray NS, Bullock AN. Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. J Mol Biol. 2014 Apr 22. pii: S0022-2836(14)00198-3. doi:, 10.1016/j.jmb.2014.04.014. PMID:24768818 doi:http://dx.doi.org/10.1016/j.jmb.2014.04.014

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