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Neurotrophin

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== Function ==
== Function ==
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'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor receptor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily.
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'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor receptor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor (BDNF) which is a member of the tumor necrosis factor receptor superfamily.
== Relevance ==
== Relevance ==

Revision as of 09:38, 1 January 2019

Glycosylated human NT3 homodimer (grey and green) complex with p75NTR (pink and yellow) (PDB code 3buk)

Drag the structure with the mouse to rotate

3D structures of neurotrophin

Updated on 01-January-2019

1b8k, 1nt3 – hNT3 – human
3buk – hNT3 + P75NTR
1bnd – hNT3 139-257 + BDNF
1b98 – hNT4 81-210
1b8m, 1hcf – hNT4 81-210 + BDNF

References

  1. ↑ Facci L, Skaper SD. Culture of rat cerebellar granule neurons and application to identify neuroprotective agents. Methods Mol Biol. 2012;846:23-37. doi: 10.1007/978-1-61779-536-7_3. PMID:22367798 doi:http://dx.doi.org/10.1007/978-1-61779-536-7_3
  2. ↑ Chao MV, Rajagopal R, Lee FS. Neurotrophin signalling in health and disease. Clin Sci (Lond). 2006 Feb;110(2):167-73. doi: 10.1042/CS20050163. PMID:16411893 doi:http://dx.doi.org/10.1042/CS20050163
  3. ↑ Gong Y, Cao P, Yu HJ, Jiang T. Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature. 2008 Aug 7;454(7205):789-93. Epub 2008 Jul 2. PMID:18596692 doi:10.1038/nature07089

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