Neurotrophin
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a <scene name='80/805035/Cv/2'>homodimer of NT3 with two symmetrically arranged p75NTR molecules</scene>. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>. | + | The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a <scene name='80/805035/Cv/2'>homodimer of NT3 with two symmetrically arranged p75NTR molecules</scene>. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>. |
| + | *<scene name='80/805035/Cv/3'>Site 1</scene>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 14:09, 1 January 2019
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3D structures of neurotrophin
Updated on 01-January-2019
1b8k, 1nt3 – hNT3 – human
3buk – hNT3 + P75NTR
1bnd – hNT3 139-257 + BDNF
1b98 – hNT4 81-210
1b8m, 1hcf – hNT4 81-210 + BDNF
References
- ↑ Facci L, Skaper SD. Culture of rat cerebellar granule neurons and application to identify neuroprotective agents. Methods Mol Biol. 2012;846:23-37. doi: 10.1007/978-1-61779-536-7_3. PMID:22367798 doi:http://dx.doi.org/10.1007/978-1-61779-536-7_3
- ↑ Chao MV, Rajagopal R, Lee FS. Neurotrophin signalling in health and disease. Clin Sci (Lond). 2006 Feb;110(2):167-73. doi: 10.1042/CS20050163. PMID:16411893 doi:http://dx.doi.org/10.1042/CS20050163
- ↑ Gong Y, Cao P, Yu HJ, Jiang T. Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature. 2008 Aug 7;454(7205):789-93. Epub 2008 Jul 2. PMID:18596692 doi:10.1038/nature07089
