3hts

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[[Image:3hts.jpg|left|200px]]
[[Image:3hts.jpg|left|200px]]
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{{Structure
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|PDB= 3hts |SIZE=350|CAPTION= <scene name='initialview01'>3hts</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_3hts", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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{{STRUCTURE_3hts| PDB=3hts | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hts OCA], [http://www.ebi.ac.uk/pdbsum/3hts PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3hts RCSB]</span>
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'''HEAT SHOCK TRANSCRIPTION FACTOR/DNA COMPLEX'''
'''HEAT SHOCK TRANSCRIPTION FACTOR/DNA COMPLEX'''
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[[Category: Littlefield, O.]]
[[Category: Littlefield, O.]]
[[Category: Nelson, H C.M.]]
[[Category: Nelson, H C.M.]]
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[[Category: complex (winged helix_turn_ helix/dna)]]
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[[Category: Dna-binding protein]]
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[[Category: dna-binding protein]]
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[[Category: Transcription regulation]]
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[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:04:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:33:56 2008''
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Revision as of 19:04, 4 May 2008

Image:3hts.jpg

Template:STRUCTURE 3hts

HEAT SHOCK TRANSCRIPTION FACTOR/DNA COMPLEX


Overview

The 1.75 A crystal structure of the Kluyveromyces lactis heat shock transcription factor (HSF) DNA-binding domain (DBD) complexed with DNA reveals a protein-DNA interface with few direct major groove contacts and a number of phosphate backbone contacts that are primarily water-mediated interactions. The DBD, a 'winged' helix-turn-helix protein, displays a novel mode of binding in that the 'wing' does not contact DNA like all others of that class. Instead, the monomeric DBD, which crystallized as a symmetric dimer to a pair of nGAAn inverted repeats, uses the 'wing' to form part of the protein-protein contacts. This dimer interface is likely important for increasing the DNA-binding specificity and affinity of the trimeric form of HSF, as well as for increasing cooperativity between adjacent trimers.

About this Structure

3HTS is a Single protein structure of sequence from Kluyveromyces lactis. Full crystallographic information is available from OCA.

Reference

A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal., Littlefield O, Nelson HC, Nat Struct Biol. 1999 May;6(5):464-70. PMID:10331875 Page seeded by OCA on Sun May 4 22:04:17 2008

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