3icd
From Proteopedia
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[[Image:3icd.jpg|left|200px]] | [[Image:3icd.jpg|left|200px]] | ||
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'''STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE''' | '''STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE''' | ||
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Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase., Hurley JH, Thorsness PE, Ramalingam V, Helmers NH, Koshland DE Jr, Stroud RM, Proc Natl Acad Sci U S A. 1989 Nov;86(22):8635-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2682654 2682654] | Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase., Hurley JH, Thorsness PE, Ramalingam V, Helmers NH, Koshland DE Jr, Stroud RM, Proc Natl Acad Sci U S A. 1989 Nov;86(22):8635-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2682654 2682654] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Isocitrate dehydrogenase (NADP(+))]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Helmers, N H.]] | [[Category: Helmers, N H.]] | ||
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[[Category: Stroud, R M.]] | [[Category: Stroud, R M.]] | ||
[[Category: Thorsness, P E.]] | [[Category: Thorsness, P E.]] | ||
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Revision as of 19:04, 4 May 2008
STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE
Overview
The structure of isocitrate dehydrogenase [threo-DS-isocitrate: NADP+ oxidoreductase (decarboxylating), EC 1.1.1.42] from Escherichia coli has been solved and refined at 2.5 A resolution and is topologically different from that of any other dehydrogenase. This enzyme, a dimer of identical 416-residue subunits, is inactivated by phosphorylation at Ser-113, which lies at the edge of an interdomain pocket that also contains many residues conserved between isocitrate dehydrogenase and isopropylmalate dehydrogenase. Isocitrate dehydrogenase contains an unusual clasp-like domain in which both polypeptide chains in the dimer interlock. Based on the structure of isocitrate dehydrogenase and conservation with isopropylmalate dehydrogenase, we suggest that the active site lies in an interdomain pocket close to the phosphorylation site.
About this Structure
3ICD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase., Hurley JH, Thorsness PE, Ramalingam V, Helmers NH, Koshland DE Jr, Stroud RM, Proc Natl Acad Sci U S A. 1989 Nov;86(22):8635-9. PMID:2682654 Page seeded by OCA on Sun May 4 22:04:40 2008
