430d
From Proteopedia
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| - | + | {{STRUCTURE_430d| PDB=430d | SCENE= }} | |
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'''STRUCTURE OF SARCIN/RICIN LOOP FROM RAT 28S RRNA''' | '''STRUCTURE OF SARCIN/RICIN LOOP FROM RAT 28S RRNA''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=430D OCA]. | |
==Reference== | ==Reference== | ||
Crystal structure of the ribosomal RNA domain essential for binding elongation factors., Correll CC, Munishkin A, Chan YL, Ren Z, Wool IG, Steitz TA, Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13436-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9811818 9811818] | Crystal structure of the ribosomal RNA domain essential for binding elongation factors., Correll CC, Munishkin A, Chan YL, Ren Z, Wool IG, Steitz TA, Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13436-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9811818 9811818] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Chan, Y-L.]] | [[Category: Chan, Y-L.]] | ||
[[Category: Correll, C C.]] | [[Category: Correll, C C.]] | ||
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[[Category: Steitz, T A.]] | [[Category: Steitz, T A.]] | ||
[[Category: Wool, I G.]] | [[Category: Wool, I G.]] | ||
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| - | [[Category: | + | [[Category: Double helix]] |
| - | [[Category: | + | [[Category: Hairpin]] |
| - | [[Category: | + | [[Category: Ribonucleic acid]] |
| - | [[Category: | + | [[Category: Tetraloop mismatched]] |
| - | [[Category: | + | [[Category: U-rna]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:17:21 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 19:17, 4 May 2008
STRUCTURE OF SARCIN/RICIN LOOP FROM RAT 28S RRNA
Overview
The structure of a 29-nucleotide RNA containing the sarcin/ricin loop (SRL) of rat 28 S rRNA has been determined at 2.1 A resolution. Recognition of the SRL by elongation factors and by the ribotoxins, sarcin and ricin, requires a nearly universal dodecamer sequence that folds into a G-bulged cross-strand A stack and a GAGA tetraloop. The juxtaposition of these two motifs forms a distorted hairpin structure that allows direct recognition of bases in both grooves as well as recognition of nonhelical backbone geometry and two 5'-unstacked purines. Comparisons with other RNA crystal structures establish the cross-strand A stack and the GNRA tetraloop as defined and modular RNA structural elements. The conserved region at the top is connected to the base of the domain by a region presumed to be flexible because of the sparsity of stabilizing contacts. Although the conformation of the SRL RNA previously determined by NMR spectroscopy is similar to the structure determined by x-ray crystallography, significant differences are observed in the "flexible" region and to a lesser extent in the G-bulged cross-strand A stack.
About this Structure
Full crystallographic information is available from OCA.
Reference
Crystal structure of the ribosomal RNA domain essential for binding elongation factors., Correll CC, Munishkin A, Chan YL, Ren Z, Wool IG, Steitz TA, Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13436-41. PMID:9811818 Page seeded by OCA on Sun May 4 22:17:21 2008
