463d

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[[Image:463d.gif|left|200px]]
[[Image:463d.gif|left|200px]]
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{{Structure
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|PDB= 463d |SIZE=350|CAPTION= <scene name='initialview01'>463d</scene>, resolution 1.45&Aring;
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The line below this paragraph, containing "STRUCTURE_463d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_463d| PDB=463d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=463d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=463d OCA], [http://www.ebi.ac.uk/pdbsum/463d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=463d RCSB]</span>
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}}
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'''CALCIUM FORM OF D(CGCGAATTCGCG)2'''
'''CALCIUM FORM OF D(CGCGAATTCGCG)2'''
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==About this Structure==
==About this Structure==
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463D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=463D OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=463D OCA].
==Reference==
==Reference==
Structure of d(CGCGAATTCGCG) in the presence of Ca(2+) ions., Liu J, Subirana JA, J Biol Chem. 1999 Aug 27;274(35):24749-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10455145 10455145]
Structure of d(CGCGAATTCGCG) in the presence of Ca(2+) ions., Liu J, Subirana JA, J Biol Chem. 1999 Aug 27;274(35):24749-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10455145 10455145]
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[[Category: Protein complex]]
 
[[Category: Liu, J.]]
[[Category: Liu, J.]]
[[Category: Subirana, J A.]]
[[Category: Subirana, J A.]]
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[[Category: ca2+ binding]]
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[[Category: Ca2+ binding]]
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[[Category: dickerson-drew dodecamer]]
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[[Category: Dickerson-drew dodecamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:19:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:37:30 2008''
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Revision as of 19:19, 4 May 2008

Image:463d.gif

Template:STRUCTURE 463d

CALCIUM FORM OF D(CGCGAATTCGCG)2


Overview

The dodecamer d(CGCGAATTCGCG) was the first oligonucleotide to be crystallized as a B-DNA duplex. Its structure was analyzed in detail in the early 1980s. Here we show that, in the presence of Ca(2+), it crystallizes in a different way (R3 space group). The dodecamers form parallel columns of straight duplexes with ten base pairs in the B form. The terminal cytosines in each molecule are disordered, whereas the terminal guanines are placed in the minor groove of neighbor duplexes. The central GAATTC region is practically identical to that found in the classic structure of the same dodecamer crystallized in the P2(1)2(1)2(1) space group in the presence of Mg(2+) and spermine. Its structure is thus independent of the crystallization conditions which have been used.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of d(CGCGAATTCGCG) in the presence of Ca(2+) ions., Liu J, Subirana JA, J Biol Chem. 1999 Aug 27;274(35):24749-52. PMID:10455145 Page seeded by OCA on Sun May 4 22:19:08 2008

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