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3lwp
From Proteopedia
(Difference between revisions)
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==Structure of H/ACA RNP bound to a substrate RNA containing 5BrdU== | ==Structure of H/ACA RNP bound to a substrate RNA containing 5BrdU== | ||
| - | <StructureSection load='3lwp' size='340' side='right' caption='[[3lwp]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3lwp' size='340' side='right'caption='[[3lwp]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3lwp]] is a 5 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3lwp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LWP FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwp OCA], [https://pdbe.org/3lwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lwp RCSB], [https://www.ebi.ac.uk/pdbsum/3lwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwp ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/TRUB_PYRFU TRUB_PYRFU]] Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity). [[http://www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). [[http://www.uniprot.org/uniprot/NOP10_PYRFU NOP10_PYRFU]] Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwp_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwp_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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==See Also== | ==See Also== | ||
*[[Guide-independent Pseudouridine synthase|Guide-independent Pseudouridine synthase]] | *[[Guide-independent Pseudouridine synthase|Guide-independent Pseudouridine synthase]] | ||
| - | *[[Ribosome biogenesis protein|Ribosome biogenesis protein]] | + | *[[Pseudouridine synthase 3D structures|Pseudouridine synthase 3D structures]] |
| + | *[[Ribosome biogenesis protein 3D structures|Ribosome biogenesis protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Li | + | [[Category: Pyrococcus furiosus]] |
| - | [[Category: Liang | + | [[Category: Li H]] |
| - | [[Category: Lv | + | [[Category: Liang B]] |
| - | [[Category: Yang | + | [[Category: Lv C]] |
| - | [[Category: Zhou | + | [[Category: Yang W]] |
| - | + | [[Category: Zhou J]] | |
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Current revision
Structure of H/ACA RNP bound to a substrate RNA containing 5BrdU
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Categories: Large Structures | Pyrococcus furiosus | Li H | Liang B | Lv C | Yang W | Zhou J
