3mff

From Proteopedia

(Difference between revisions)

Revision as of 06:41, 14 October 2020

1F1E8hu TCR

Structural highlights

3mff is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Alphabeta T-cell receptors (TcRs) play a central role in cellular immune response. They are members of the Ig superfamily, with extracellular regions of the alpha and beta chains each comprising a V-type domain and a C-type domain. We have determined the ectodomain structure of an alphabeta TcR, which recognizes the autoantigen myelin basic protein. The 2.0-A-resolution structure reveals canonical main-chain conformations for the V(alpha), V(beta), and C(beta) domains, but the C(alpha) domain exhibits a main-chain conformation remarkably different from those previously reported for TcR crystal structures. The global IgC-like fold is maintained, but a piston-like rearrangement between BC and DE beta-turns results in beta-strand slippage. This substantial conformational change may represent a signaling intermediate. Our structure is the first example for the Ig fold of the increasingly recognized concept of "metamorphic proteins."

An alternative conformation of the T-cell receptor alpha constant region.,van Boxel GI, Holmes S, Fugger L, Jones EY J Mol Biol. 2010 Jul 23;400(4):828-37. Epub 2010 May 31. PMID:20630474^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ van Boxel GI, Holmes S, Fugger L, Jones EY. An alternative conformation of the T-cell receptor alpha constant region. J Mol Biol. 2010 Jul 23;400(4):828-37. Epub 2010 May 31. PMID:20630474 doi:http://dx.doi.org/10.1016/j.jmb.2010.05.053

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3mff"

@@ Line 1: / Line 1: @@
 ==1F1E8hu TCR==
-<StructureSection load='3mff' size='340' side='right' caption='[[3mff]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='3mff' size='340' side='right'caption='[[3mff]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3mff]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MFF FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3mff]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3MFF FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mff OCA], [http://pdbe.org/3mff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mff RCSB], [http://www.ebi.ac.uk/pdbsum/3mff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mff ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3mff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mff OCA], [http://pdbe.org/3mff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mff RCSB], [http://www.ebi.ac.uk/pdbsum/3mff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mff ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 28: / Line 28: @@
 ==See Also==
-*[[T-cell receptor|T-cell receptor]]
+*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
 == References ==
 <references/>
@@ Line 34: / Line 34: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Boxel, G I.van]]
 [[Category: Fugger, L]]

3mff

From Proteopedia

Revision as of 06:41, 14 October 2020

1F1E8hu TCR

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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