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3m7p

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Fibronectin fragment

Structural highlights

3m7p is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Fibronectin is a modular extracellular matrix protein involved in cell adhesion, cell motility, wound healing, and maintenance of cell morphology. It is composed of multiple repeats of three distinct modules: F(I), F(II), and F(III). Various combinations of these modules create fragments able to interact with different constituents of the extracellular matrix. Here, we present the 2.5-A resolution crystal structure of its 45-kDa gelatin-binding domain (GBD; 6F(I)-1F(II)-2F(II)-7F(I)-8F(I)-9F(I)), which also corresponds to the C-terminal half of the migration stimulating factor, a Fn splice variant expressed in human breast cancers. GBD forms a very compact zinc-mediated homodimer, in stark contrast with previous structures of fibronectin fragments. Most remarkably, 8F(I) no longer adopts the canonical F(I) fold but is composed of two long strands that associate with 7F(I) and 9F(I) into a large beta-sheet superdomain. Binding studies in solution confirmed that Zn induces conformational rearrangements and causes loss of binding of Fn-GBD to high-affinity collagen peptides. These data suggest the Zn may play a regulatory role for the cellular functions of fibronectin.

Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding.,Graille M, Pagano M, Rose T, Ravaux MR, van Tilbeurgh H Structure. 2010 Jun 9;18(6):710-8. PMID:20541508^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Graille M, Pagano M, Rose T, Ravaux MR, van Tilbeurgh H. Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding. Structure. 2010 Jun 9;18(6):710-8. PMID:20541508 doi:10.1016/j.str.2010.03.012

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3m7p"

@@ Line 1: / Line 1: @@
 ==Fibronectin fragment==
-<StructureSection load='3m7p' size='340' side='right' caption='[[3m7p]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='3m7p' size='340' side='right'caption='[[3m7p]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3m7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M7P FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3m7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3M7P FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7p OCA], [http://pdbe.org/3m7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m7p RCSB], [http://www.ebi.ac.uk/pdbsum/3m7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m7p ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3m7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7p OCA], [http://pdbe.org/3m7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m7p RCSB], [http://www.ebi.ac.uk/pdbsum/3m7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m7p ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 29: / Line 29: @@
 ==See Also==
 *[[Fibronectin|Fibronectin]]
+*[[Fibronectin 3D structures|Fibronectin 3D structures]]
 == References ==
 <references/>
@@ Line 34: / Line 35: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Graille, M]]
 [[Category: Pagano, M]]

3m7p

From Proteopedia

Current revision

Fibronectin fragment

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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