4gal

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[[Image:4gal.jpg|left|200px]]
[[Image:4gal.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_4gal", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>
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{{STRUCTURE_4gal| PDB=4gal | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gal OCA], [http://www.ebi.ac.uk/pdbsum/4gal PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4gal RCSB]</span>
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'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE'''
'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE'''
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[[Category: Acharya, K R.]]
[[Category: Acharya, K R.]]
[[Category: Leonidas, D D.]]
[[Category: Leonidas, D D.]]
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[[Category: carbohydrate binding]]
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[[Category: Carbohydrate binding]]
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[[Category: galaptin]]
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[[Category: Galaptin]]
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[[Category: galectin]]
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[[Category: Galectin]]
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[[Category: lectin]]
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[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:24:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:38:47 2008''
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Revision as of 19:24, 4 May 2008

Image:4gal.jpg

Template:STRUCTURE 4gal

CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE


Overview

Knowledge about carbohydrate recognition domains of galectins, formerly known as S-type animal lectins, is important in understanding their role(s) in cell-cell interactions. Here we report the crystal structure of human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This is the first structure of a galectin determined in both free and carbohydrate-bound forms. The structure shows a fold similar to that of the prototype galectins -1 and -2, but has greater similarity to a related galectin molecule, Gal-10. Even though the carbohydrate-binding residues are conserved, there are significant changes in this pocket due to shortening of a loop structure. The monomeric hGal-7 molecule exists as a dimer in the crystals, but adopts a packing arrangement considerably different from that of Gal-1 and Gal-2, which has implications for carbohydrate recognition.

About this Structure

4GAL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:9760227 Page seeded by OCA on Sun May 4 22:24:16 2008

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