4fua

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:4fua.jpg|left|200px]]
[[Image:4fua.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 4fua |SIZE=350|CAPTION= <scene name='initialview01'>4fua</scene>, resolution 2.43&Aring;
+
The line below this paragraph, containing "STRUCTURE_4fua", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=ACT:The+Active+Center+Is+Defined+By+The+Zn+Ion,+The+Four+Zn+...'>ACT</scene> and <scene name='pdbsite=PBS:Binding+Site+For+The+Substrate+Phosphate+Group'>PBS</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PGH:PHOSPHOGLYCOLOHYDROXAMIC+ACID'>PGH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/L-fuculose-phosphate_aldolase L-fuculose-phosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.17 4.1.2.17] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_4fua| PDB=4fua | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fua OCA], [http://www.ebi.ac.uk/pdbsum/4fua PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4fua RCSB]</span>
+
-
}}
+
'''L-FUCULOSE-1-PHOSPHATE ALDOLASE COMPLEX WITH PGH'''
'''L-FUCULOSE-1-PHOSPHATE ALDOLASE COMPLEX WITH PGH'''
Line 28: Line 25:
[[Category: Dreyer, M K.]]
[[Category: Dreyer, M K.]]
[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
-
[[Category: class ii aldolase]]
+
[[Category: Class ii aldolase]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: zinc enzyme]]
+
[[Category: Zinc enzyme]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:24:03 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:38:46 2008''
+

Revision as of 19:24, 4 May 2008

Image:4fua.jpg

Template:STRUCTURE 4fua

L-FUCULOSE-1-PHOSPHATE ALDOLASE COMPLEX WITH PGH


Overview

The structure of L-fuculose-1-phosphate aldolase in a cubic crystal form has been determined with and without the inhibitor phosphoglycolohydroxamate at 2.4 and 2.7 angstrom (1 angstrom = 0.1 nm) resolution, respectively. This inhibitor mimics the enediolate transition state of the substrate moiety dihydroxyacetone phosphate. The structures showed that dihydroxyacetone phosphate ligates the zinc ion of this metal-dependent class II aldolase with its hydroxyl and keto oxygen atoms, shifting Glu73 away from the zinc coordination sphere to a non-polar environment. At this position Glu73 accepts a proton in the initial reaction step, producing the enediolate which is then stabilized by the zinc ion. The other substrate moiety L-lactaldehyde was modeled, because no binding structure is yet available.

About this Structure

4FUA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure., Dreyer MK, Schulz GE, J Mol Biol. 1996 Jun 14;259(3):458-66. PMID:8676381 Page seeded by OCA on Sun May 4 22:24:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fua"
Personal tools