Sandbox Reserved 1495
From Proteopedia
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== Generalities == | == Generalities == | ||
| - | Clathrin is a 3 legged protein with 3 heavy chains and 3 light chains. It has a '''triskelion''' shape and can self-assembled into a '''polyhedral''' structure arround vesicles of eukaryotic cells | + | Clathrin is a 3 legged protein with 3 heavy chains and 3 light chains. It has a '''triskelion''' shape and can self-assembled into a '''polyhedral''' structure arround vesicles of eukaryotic cells. |
| - | + | ||
<Structure load='3LVG' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='3LVG' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
== Function == | == Function == | ||
| - | Communication beetween the different compartiments of eukaryotic cell and plasma membrane is allowed by vesicles, which convey molecules within the cytoplasm. | + | Communication beetween the different compartiments of eukaryotic cell and plasma membrane is allowed by vesicles, which convey molecules within the cytoplasm. Clathrin are involved in the formation of those vesicles in a process named clathrin mediated endocytosis. Clathrins form a skeleton around the vesicle once several protein are assembled. The coated vesicles like so formed will then lose their round protein skeleton after their departure from the initial compartment because the clathrin cage is dismantled. |
| - | + | This phenomena proceeds through five stages that correspond to ultrastructural and cell biological observations: initiation, cargo selection, coat assembly, scission and uncoating. During the cargo selection and the initiation, clathrins polymerize into hexagons and pentagons. | |
== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 14:54, 10 January 2019
Contents |
Generalities
Clathrin is a 3 legged protein with 3 heavy chains and 3 light chains. It has a triskelion shape and can self-assembled into a polyhedral structure arround vesicles of eukaryotic cells.
|
Function
Communication beetween the different compartiments of eukaryotic cell and plasma membrane is allowed by vesicles, which convey molecules within the cytoplasm. Clathrin are involved in the formation of those vesicles in a process named clathrin mediated endocytosis. Clathrins form a skeleton around the vesicle once several protein are assembled. The coated vesicles like so formed will then lose their round protein skeleton after their departure from the initial compartment because the clathrin cage is dismantled. This phenomena proceeds through five stages that correspond to ultrastructural and cell biological observations: initiation, cargo selection, coat assembly, scission and uncoating. During the cargo selection and the initiation, clathrins polymerize into hexagons and pentagons.
Relevance
Structural highlights
</StructureSection>
References
Molecular mechanism and physiological functions of clathrin‑mediated endocytosisVOLUME 12 | AUGUST 2011 Harvey T. McMahon and Emmanuel Boucrot VOLUME 12 | AUGUST 2011
