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6mq5

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'''Unreleased structure'''
 
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The entry 6mq5 is ON HOLD until Oct 09 2020
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==Structure of human CLASP1 TOG1==
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<StructureSection load='6mq5' size='340' side='right'caption='[[6mq5]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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Authors: Leano, J.B., Slep, K.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mq5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQ5 FirstGlance]. <br>
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Description: Structure of human CLASP1 TOG1
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mq5 OCA], [http://pdbe.org/6mq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mq5 RCSB], [http://www.ebi.ac.uk/pdbsum/6mq5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mq5 ProSAT]</span></td></tr>
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[[Category: Leano, J.B]]
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</table>
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[[Category: Slep, K.C]]
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== Function ==
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[[http://www.uniprot.org/uniprot/CLAP1_HUMAN CLAP1_HUMAN]] Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.<ref>PMID:11290329</ref> <ref>PMID:12837247</ref> <ref>PMID:15631994</ref> <ref>PMID:16866869</ref> <ref>PMID:16914514</ref> <ref>PMID:17543864</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Leano, J B]]
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[[Category: Slep, K C]]
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[[Category: Microtubule plus end binding]]
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[[Category: Structural protein]]

Revision as of 10:44, 17 July 2019

Structure of human CLASP1 TOG1

PDB ID 6mq5

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