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5cac

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[[Image:5cac.gif|left|200px]]
[[Image:5cac.gif|left|200px]]
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{{Structure
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|PDB= 5cac |SIZE=350|CAPTION= <scene name='initialview01'>5cac</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_5cac", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
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{{STRUCTURE_5cac| PDB=5cac | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cac OCA], [http://www.ebi.ac.uk/pdbsum/5cac PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5cac RCSB]</span>
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}}
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'''REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION'''
'''REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION'''
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[[Category: Liljas, A.]]
[[Category: Liljas, A.]]
[[Category: Lindahl, M.]]
[[Category: Lindahl, M.]]
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[[Category: lyase(oxo-acid)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:32:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:40:55 2008''
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Revision as of 19:32, 4 May 2008

Image:5cac.gif

Template:STRUCTURE 5cac

REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION


Overview

The structure of human erythrocytic carbonic anhydrase II has been refined by constrained and restrained structure-factor least-squares refinement at 2.0 A resolution. The conventional crystallographic R value is 17.3%. Of 167 solvent molecules associated with the protein, four are buried and stabilize secondary structure elements. The zinc ion is ligated to three histidyl residues and one water molecule in a nearly tetrahedral geometry. In addition to the zinc-bound water, seven more water molecules are identified in the active site. Assuming that Glu-106 is deprotonated at pH 8.5, some of the hydrogen bond donor-acceptor relations in the active site can be assigned and are described here in detail. The O gamma 1 atom of Thr-199 donates its proton to the O epsilon 1 atom of Glu-106 and can function as a hydrogen bond acceptor only in additional hydrogen bonds.

About this Structure

5CAC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Refined structure of human carbonic anhydrase II at 2.0 A resolution., Eriksson AE, Jones TA, Liljas A, Proteins. 1988;4(4):274-82. PMID:3151019 Page seeded by OCA on Sun May 4 22:32:26 2008

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