5hck

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:5hck.gif|left|200px]]
[[Image:5hck.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 5hck |SIZE=350|CAPTION= <scene name='initialview01'>5hck</scene>
+
The line below this paragraph, containing "STRUCTURE_5hck", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.7.112 2.1.7.112] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= RESIDUES G72-E143 OF HUMAN HCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_5hck| PDB=5hck | SCENE= }}
-
|RELATEDENTRY=[[4hck|4HCK]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hck OCA], [http://www.ebi.ac.uk/pdbsum/5hck PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5hck RCSB]</span>
+
-
}}
+
'''HUMAN HCK SH3 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE'''
'''HUMAN HCK SH3 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE'''
Line 33: Line 30:
[[Category: Smithgall, T E.]]
[[Category: Smithgall, T E.]]
[[Category: Zhang, W.]]
[[Category: Zhang, W.]]
-
[[Category: protein tyrosine kinase]]
+
[[Category: Protein tyrosine kinase]]
-
[[Category: sh3]]
+
[[Category: Sh3]]
-
[[Category: signal transduction]]
+
[[Category: Signal transduction]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:34:58 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:41:37 2008''
+

Revision as of 19:35, 4 May 2008

Image:5hck.gif

Template:STRUCTURE 5hck

HUMAN HCK SH3 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE


Overview

SH3 domains are protein binding domains that occur widely among signal transduction proteins. Here, we present the NMR-determined solution structure of the SH3 domain from the cytoplasmic protein tyrosine kinase, Hck. Hck is involved in a number of cell signal transduction pathways, frequently in pathways associated with immune response. SH3 domains bind proteins via a left-handed polyproline type II helix on the target protein. We have assessed the structural impact of binding to a ligand through addition of a peptide corresponding to a proline-rich region of a Hck target, the GTPase activating protein of the Ras pathway. Ligand binding effects small structural changes and stabilizes the SH3 domain structure. Also, we have compared the solution structure of the Hck SH3 domain to the crystal structure of Hck, in which the SH3 domain exhibits an intramolecular binding to an interdomain linker region. These structures are interpreted as the apo- and holo- forms of the Hck SH3 domain.

About this Structure

5HCK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the human Hck SH3 domain and identification of its ligand binding site., Horita DA, Baldisseri DM, Zhang W, Altieri AS, Smithgall TE, Gmeiner WH, Byrd RA, J Mol Biol. 1998 Apr 24;278(1):253-65. PMID:9571048 Page seeded by OCA on Sun May 4 22:34:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5hck"
Personal tools