5pgm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:5pgm.gif|left|200px]]
[[Image:5pgm.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 5pgm |SIZE=350|CAPTION= <scene name='initialview01'>5pgm</scene>, resolution 2.12&Aring;
+
The line below this paragraph, containing "STRUCTURE_5pgm", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=CIA:Catalytic+Site.+HIS+8+Phosphorylation+Is+Required+To+Pri+...'>CIA</scene>, <scene name='pdbsite=CIB:Catalytic+Site.+HIS+8+Phosphorylation+Is+Required+To+Pri+...'>CIB</scene>, <scene name='pdbsite=CIC:Catalytic+Site.+HIS+8+Phosphorylation+Is+Required+To+Pri+...'>CIC</scene>, <scene name='pdbsite=CID:Catalytic+Site.+HIS+8+Phosphorylation+Is+Required+To+Pri+...'>CID</scene>, <scene name='pdbsite=CIE:Catalytic+Site.+HIS+8+Phosphorylation+Is+Required+To+Pri+...'>CIE</scene>, <scene name='pdbsite=CIF:Catalytic+Site.+HIS+8+Phosphorylation+Is+Required+To+Pri+...'>CIF</scene>, <scene name='pdbsite=CIG:Catalytic+Site.+HIS+8+Phosphorylation+Is+Required+To+Pri+...'>CIG</scene> and <scene name='pdbsite=CIH:Catalytic+Site.+HIS+8+Phosphorylation+Is+Required+To+Pri+...'>CIH</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_5pgm| PDB=5pgm | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pgm OCA], [http://www.ebi.ac.uk/pdbsum/5pgm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5pgm RCSB]</span>
+
-
}}
+
'''SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE'''
'''SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE'''
Line 29: Line 26:
[[Category: Phillips, S E.V.]]
[[Category: Phillips, S E.V.]]
[[Category: Rigden, D J.]]
[[Category: Rigden, D J.]]
-
[[Category: glycolytic enzyme]]
+
[[Category: Glycolytic enzyme]]
-
[[Category: isomerase]]
+
[[Category: Isomerase]]
-
[[Category: transferase (phosphoryl)]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:37:00 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:42:04 2008''
+

Revision as of 19:37, 4 May 2008

Image:5pgm.gif

Template:STRUCTURE 5pgm

SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE


Overview

The structure of a new crystal form of Saccharomyces cerevisiae phosphoglycerate mutase has been solved and refined to 2.12 A with working and free R-factors of 19.7 and 22.9 %, respectively. Higher-resolution data and greater non-crystallographic symmetry have produced a more accurate protein structure than previously. Prominent among the differences from the previous structure is the presence of two sulphate ions within each active site cleft. The separation of the sulphates suggests that they may occupy the same sites as phospho groups of the bisphosphate ligands of the enzyme. Plausible binding modes for 2,3-bisphosphoglycerate and 1, 3-bisphosphoglycerate are thereby suggested. These results support previous conclusions from mutant studies, highlight interesting new targets for mutagenesis and suggest a possible mechanism of enzyme phosphorylation.

About this Structure

5PGM is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Sulphate ions observed in the 2.12 A structure of a new crystal form of S. cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism., Rigden DJ, Walter RA, Phillips SE, Fothergill-Gilmore LA, J Mol Biol. 1999 Mar 12;286(5):1507-17. PMID:10064712 Page seeded by OCA on Sun May 4 22:37:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5pgm"
Personal tools