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3msj

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Current revision (09:00, 6 September 2023) (edit) (undo)
 
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==Structure of bace (beta secretase) in complex with inhibitor==
==Structure of bace (beta secretase) in complex with inhibitor==
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<StructureSection load='3msj' size='340' side='right' caption='[[3msj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3msj' size='340' side='right'caption='[[3msj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3msj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MSJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3msj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MSJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EV3:3-(2-AMINO-5-CHLORO-1H-BENZIMIDAZOL-1-YL)PROPAN-1-OL'>EV3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EV3:3-(2-AMINO-5-CHLORO-1H-BENZIMIDAZOL-1-YL)PROPAN-1-OL'>EV3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3msj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3msj OCA], [https://pdbe.org/3msj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3msj RCSB], [https://www.ebi.ac.uk/pdbsum/3msj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3msj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3msj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3msj OCA], [http://pdbe.org/3msj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3msj RCSB], [http://www.ebi.ac.uk/pdbsum/3msj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3msj ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Beta secretase|Beta secretase]]
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Large Structures]]
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[[Category: Barker, J]]
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[[Category: Barker J]]
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[[Category: Godemann, R]]
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[[Category: Godemann R]]
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[[Category: Kramer, J]]
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[[Category: Kramer J]]
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[[Category: Madden, J]]
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[[Category: Madden J]]
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[[Category: Smith, M A]]
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[[Category: Smith MA]]
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[[Category: Alzheimer's disease]]
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[[Category: Amyloid precursor protein secretase]]
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[[Category: Aspartic endopeptidase]]
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[[Category: Aspartic protease]]
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[[Category: Aspartyl protease]]
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[[Category: Base]]
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[[Category: Beta-secretase]]
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[[Category: Fluorescence polarisation]]
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[[Category: Fragment-based drug design]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease]]
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[[Category: Transmembrane]]
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[[Category: Zymogen]]
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Current revision

Structure of bace (beta secretase) in complex with inhibitor

PDB ID 3msj

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