3mpp
From Proteopedia
(Difference between revisions)
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==Botulinum Neurotoxin Type G Receptor Binding Domain== | ==Botulinum Neurotoxin Type G Receptor Binding Domain== | ||
| - | <StructureSection load='3mpp' size='340' side='right' caption='[[3mpp]], [[Resolution|resolution]] 1.98Å' scene=''> | + | <StructureSection load='3mpp' size='340' side='right'caption='[[3mpp]], [[Resolution|resolution]] 1.98Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3mpp]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3mpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MPP FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">botG ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">botG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpp OCA], [https://pdbe.org/3mpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mpp RCSB], [https://www.ebi.ac.uk/pdbsum/3mpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mpp ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/BXG_CLOBO BXG_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Botulinum neurotoxin|Botulinum neurotoxin]] | + | *[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Bacillus botulinus van ermengem 1896]] | [[Category: Bacillus botulinus van ermengem 1896]] | ||
[[Category: Bontoxilysin]] | [[Category: Bontoxilysin]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lacy, D B]] | [[Category: Lacy, D B]] | ||
[[Category: Schmitt, J M]] | [[Category: Schmitt, J M]] | ||
[[Category: Beta barrel beta trefoil]] | [[Category: Beta barrel beta trefoil]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 05:42, 6 October 2021
Botulinum Neurotoxin Type G Receptor Binding Domain
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