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6msf

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[[Image:6msf.gif|left|200px]]
[[Image:6msf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 6msf |SIZE=350|CAPTION= <scene name='initialview01'>6msf</scene>, resolution 2.800&Aring;
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The line below this paragraph, containing "STRUCTURE_6msf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= COAT PROTEIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12022 Enterobacterio phage MS2])
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-->
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|DOMAIN=
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{{STRUCTURE_6msf| PDB=6msf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6msf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6msf OCA], [http://www.ebi.ac.uk/pdbsum/6msf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=6msf RCSB]</span>
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}}
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'''F6 APTAMER MS2 COAT PROTEIN COMPLEX'''
'''F6 APTAMER MS2 COAT PROTEIN COMPLEX'''
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[[Category: Stockley, P G.]]
[[Category: Stockley, P G.]]
[[Category: Stonehouse, N J.]]
[[Category: Stonehouse, N J.]]
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[[Category: bacteriophage ms2]]
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[[Category: Bacteriophage ms2]]
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[[Category: icosahedral virus]]
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[[Category: Icosahedral virus]]
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[[Category: rna aptamer]]
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[[Category: Rna aptamer]]
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[[Category: rna stem loop]]
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[[Category: Rna stem loop]]
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[[Category: viral coat protein/rna complex]]
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[[Category: Viral coat protein/rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:41:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:43:19 2008''
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Revision as of 19:41, 4 May 2008

Image:6msf.gif

Template:STRUCTURE 6msf

F6 APTAMER MS2 COAT PROTEIN COMPLEX


Overview

The crystal structure, at 2.8 A resolution, of an RNA aptamer bound to bacteriophage MS2 coat protein has been determined. It provides an opportunity to compare the interactions of MS2 coat protein and wild type operator with those of an aptamer, whose secondary structure differs from the wild type RNA in having a three-base loop (compared to a tetraloop) and an additional base pair between this loop and the sequence-specific recognition element in the stem. The RNA binds in the same location on the coat protein as the wild type operator and maintains many of the same RNA-protein interactions. In order to achieve this, the RNA stem loop undergoes a concerted rearrangement of the 3' side while leaving the 5' side and the loop interactions largely unchanged, illustrating the ability of RNA to present similar molecular recognition surfaces from distinct primary and secondary structures.

About this Structure

6MSF is a Single protein structure of sequence from Enterobacterio phage ms2. Full crystallographic information is available from OCA.

Reference

Crystal structure of an RNA aptamer-protein complex at 2.8 A resolution., Convery MA, Rowsell S, Stonehouse NJ, Ellington AD, Hirao I, Murray JB, Peabody DS, Phillips SE, Stockley PG, Nat Struct Biol. 1998 Feb;5(2):133-9. PMID:9461079 Page seeded by OCA on Sun May 4 22:41:47 2008

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