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Aldehyde dehydrogenase

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Line 29: Line 29:
*<scene name='44/447036/Cv/10'>Dithiothreitol binding</scene>.
*<scene name='44/447036/Cv/10'>Dithiothreitol binding</scene>.
*<scene name='44/447036/Cv/11'>Dimercaptobutane-diol binding</scene>.
*<scene name='44/447036/Cv/11'>Dimercaptobutane-diol binding</scene>.
 +
 +
== 3D Structures of aldehyde dehydrogenase ==
 +
[[Aldehyde dehydrogenase 3D structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of Aldehyde dehydrogenase ==
== 3D Structures of Aldehyde dehydrogenase ==
Line 75: Line 79:
**[[1a4z]] – bALDH2 NAD-binding domain + NAD<BR />
**[[1a4z]] – bALDH2 NAD-binding domain + NAD<BR />
**[[1bi9]] – rALDH2 + NAD<br />
**[[1bi9]] – rALDH2 + NAD<br />
-
**[[4pxl]] – ALDH2 + NAD - maize<br />
+
**[[4pxl]] – mALDH2 + NAD - maize<br />
 +
**[[4pz2]] – mALDH6 + NAD <br />
 +
**[[6d97]] – mALDH12 + NAD <br />
*ALDH2 ternary complex
*ALDH2 ternary complex
Line 102: Line 108:
**[[4qje]] - Betaine-SaALDH (mutant)<br />
**[[4qje]] - Betaine-SaALDH (mutant)<br />
**[[4zxu]], [[4zwl]] - Betaine-SaALDH (mutant) + NAD<br />
**[[4zxu]], [[4zwl]] - Betaine-SaALDH (mutant) + NAD<br />
-
**[[4cbb]] - Betaine-PaALDH - ''Pseudomonas aeruginosa''<br />
+
**[[4cbb]], [[6bpg]] - Betaine-PaALDH - ''Pseudomonas aeruginosa''<br />
 +
**[[6bjp]] - Betaine-PaALDH (mutant)<br />
**[[1a4s]] - Betaine-cALDH - cod<BR />
**[[1a4s]] - Betaine-cALDH - cod<BR />
**[[3vos]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR />
**[[3vos]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR />
Line 117: Line 124:
**[[4qet]] – BcALDH (mutant)<br />
**[[4qet]] – BcALDH (mutant)<br />
**[[5uju]] - BmALDH – ''Burkholderia multivorans''<br />
**[[5uju]] - BmALDH – ''Burkholderia multivorans''<br />
 +
**[[6fk3]], [[6fkv]], [[6fjv]] - TtALDH – ''Thermus thermophilus''<br />
*NAD-dependent ALDH binary complexes
*NAD-dependent ALDH binary complexes
Line 124: Line 132:
**[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - Betaine-SaALDH (mutant) + NAD<br />
**[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - Betaine-SaALDH (mutant) + NAD<br />
**[[1bpw]] - Betaine-cALDH + NAD<BR />
**[[1bpw]] - Betaine-cALDH + NAD<BR />
-
**[[2j6l]] – Aminoadipate-semi-hALDH family 7 + NAD<BR />
+
**[[4zvw]], [[4zvx]] - Aminoadipate-semi-hALDH family 7<br />
 +
**[[2j6l]], [[4zvy]] – Aminoadipate-semi-hALDH family 7 + NAD<BR />
 +
**[[4x0u]] - Aminoadipate-semi-hALDH family 7+ inhibitor<br />
 +
**[[4zuk]] - Aminoadipate-semi-hALDH family 7+ NAD<br />
 +
**[[4zul]] - Aminoadipate-semi-hALDH family 7+ α-aminoadipate<br />
**[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR />
**[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR />
**[[2nad]] - Formate-PaALDH + NAD <BR />
**[[2nad]] - Formate-PaALDH + NAD <BR />
Line 138: Line 150:
**[[5gtk]] – BcALDH + NAD<br />
**[[5gtk]] – BcALDH + NAD<br />
**[[5jfl]] – RpALDH + NAD – ''Rhodopseudomonas palustris''<br />
**[[5jfl]] – RpALDH + NAD – ''Rhodopseudomonas palustris''<br />
 +
**[[6gvs]] – RpALDH + NADP <br />
**[[5jfn]] – RpALDH + CoA <br />
**[[5jfn]] – RpALDH + CoA <br />
 +
**[[6fku]] – TtALDH + NADP <br />
*NAD-dependent ALDH ternary complexes
*NAD-dependent ALDH ternary complexes
Line 148: Line 162:
**[[4i3x]] – SmALDH + phosphonoacete + NAD<br />
**[[4i3x]] – SmALDH + phosphonoacete + NAD<br />
**[[5jfm]] – RpALDH + CoA + propionyl-CoA<br />
**[[5jfm]] – RpALDH + CoA + propionyl-CoA<br />
 +
**[[4x0t]] - Aminoadipate-semi-hALDH family 7 + NAD+ inhibitor<br />
*NADP-dependent ALDH
*NADP-dependent ALDH
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**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />
**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />
**[[1ywg]] – PfGAPDH – ''Plasmodium falciparum''<br />
**[[1ywg]] – PfGAPDH – ''Plasmodium falciparum''<br />
-
**[[3cmc]] - GAPDH – ''Bacillus stearothermophilus''<br />
 
**[[2ep7]] – GAPDH – ''Aquifex aeolicus''<br />
**[[2ep7]] – GAPDH – ''Aquifex aeolicus''<br />
**[[2i5p]] – GAPDH – ''Kluyveromyces marxianus''<br />
**[[2i5p]] – GAPDH – ''Kluyveromyces marxianus''<br />
**[[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<br />
**[[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<br />
**[[1b7g]] – GAPDH – ''Sulfolobus solfataricus''<br />
**[[1b7g]] – GAPDH – ''Sulfolobus solfataricus''<br />
-
**[[2gd1]] – GsGAPDH – ''Geobacillus stearothermophilus''<br />
+
**[[2gd1]], [[3cmc]] – GsGAPDH – ''Geobacillus stearothermophilus''<br />
**[[3e6a]] – OsGAPDH – ''Oryza sativa''<br />
**[[3e6a]] – OsGAPDH – ''Oryza sativa''<br />
**[[4gpd]], [[1gpd]], [[1crw]] – GAPDH – lobster<br />
**[[4gpd]], [[1gpd]], [[1crw]] – GAPDH – lobster<br />
Line 274: Line 288:
**[[5mz8]] – PhpALDH 21 + succinate<br />
**[[5mz8]] – PhpALDH 21 + succinate<br />
**[[5n5s]] – PhpALDH 21 + NADP<br />
**[[5n5s]] – PhpALDH 21 + NADP<br />
 +
**[[6mvr]] – LoALDH 16 - ''Loktanella''<br />
 +
**[[6mvu]] – LoALDH 16 (mutant)<br />
 +
**[[6mvs]], [[6mvt]] – LoALDH 16 + NAD<br />
*Antiquitin
*Antiquitin

Revision as of 10:02, 4 March 2019

Aldehyde hydrogenase class 1 tetramer complex with NAD, dithiothreitol and dimercaptobutane-diol, 1o9j

Drag the structure with the mouse to rotate

3D Structures of Aldehyde dehydrogenase

Updated on 04-March-2019

References

  1. ↑ Keller, Markus A.; Zander, Ulrich; Fuchs, Julian E.; Kreutz, Christoph; Watschinger, Katrin et al. (2014). A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nature Communications vol. 5.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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