6req

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[[Image:6req.gif|left|200px]]
[[Image:6req.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 6req |SIZE=350|CAPTION= <scene name='initialview01'>6req</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_6req", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=3CP:3-CARBOXYPROPYL-COENZYME+A'>3CP</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_mutase Methylmalonyl-CoA mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.2 5.4.99.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= MUTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium freudenreichii subsp. shermanii]), MUTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium freudenreichii subsp. shermanii])
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-->
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|DOMAIN=
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{{STRUCTURE_6req| PDB=6req | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6req FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6req OCA], [http://www.ebi.ac.uk/pdbsum/6req PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=6req RCSB]</span>
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}}
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'''METHYLMALONYL-COA MUTASE, 3-CARBOXYPROPYL-COA INHIBITOR COMPLEX'''
'''METHYLMALONYL-COA MUTASE, 3-CARBOXYPROPYL-COA INHIBITOR COMPLEX'''
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[[Category: Evans, P R.]]
[[Category: Evans, P R.]]
[[Category: Mancia, F.]]
[[Category: Mancia, F.]]
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[[Category: intramolecular transferase]]
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[[Category: Intramolecular transferase]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: mutase]]
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[[Category: Mutase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:42:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:43:32 2008''
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Revision as of 19:42, 4 May 2008

Image:6req.gif

Template:STRUCTURE 6req

METHYLMALONYL-COA MUTASE, 3-CARBOXYPROPYL-COA INHIBITOR COMPLEX


Overview

X-ray crystal structures of methylmalonyl-CoA mutase in complexes with substrate methylmalonyl-CoA and inhibitors 2-carboxypropyl-CoA and 3-carboxypropyl-CoA (substrate and product analogues) show that the enzyme-substrate interactions change little during the course of the rearrangement reaction, in contrast to the large conformational change on substrate binding. The substrate complex shows a 5'-deoxyadenine molecule in the active site, bound weakly and not attached to the cobalt atom of coenzyme B12, rotated and shifted from its position in the substrate-free adenosylcobalamin complex. The position of Tyralpha89 close to the substrate explains the stereochemical selectivity of the enzyme for (2R)-methylmalonyl-CoA.

About this Structure

6REQ is a Protein complex structure of sequences from Propionibacterium freudenreichii subsp. shermanii. Full crystallographic information is available from OCA.

Reference

Crystal structure of substrate complexes of methylmalonyl-CoA mutase., Mancia F, Smith GA, Evans PR, Biochemistry. 1999 Jun 22;38(25):7999-8005. PMID:10387043 Page seeded by OCA on Sun May 4 22:42:42 2008

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