6tmn

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[[Image:6tmn.gif|left|200px]]
[[Image:6tmn.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 6tmn |SIZE=350|CAPTION= <scene name='initialview01'>6tmn</scene>, resolution 1.6&Aring;
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The line below this paragraph, containing "STRUCTURE_6tmn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=1LU:4-METHYL-PENTANOIC+ACID-2-OXYL+GROUP'>1LU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGL:AMINOMETHYLENEPHOSPHINIC+ACID'>PGL</scene>, <scene name='pdbligand=PHQ:FORMIC+ACID+BENZYL+ESTER'>PHQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_6tmn| PDB=6tmn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tmn OCA], [http://www.ebi.ac.uk/pdbsum/6tmn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=6tmn RCSB]</span>
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}}
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'''STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND'''
'''STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND'''
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==About this Structure==
==About this Structure==
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6TMN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMN OCA].
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6TMN is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TMN OCA].
==Reference==
==Reference==
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[[Category: Matthews, B W.]]
[[Category: Matthews, B W.]]
[[Category: Tronrud, D E.]]
[[Category: Tronrud, D E.]]
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[[Category: hydrolase (metalloproteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:43:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:43:40 2008''
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Revision as of 19:43, 4 May 2008

Image:6tmn.gif

Template:STRUCTURE 6tmn

STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND


Overview

The mode of binding to thermolysin of the ester analog Cbz-GlyP-(O)-Leu-Leu has been determined by x-ray crystallography and shown to be virtually identical (maximum difference 0.2 angstrom) with the corresponding peptide analog Cbz-GlyP-(NH)-Leu-Leu. The two inhibitors provide a matched pair of enzyme-inhibitor complexes that differ by 4.1 kilocalories per mole in intrinsic binding energy but are essentially identical except for the presence or absence of a specific hydrogen bond.

About this Structure

6TMN is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:3810156 Page seeded by OCA on Sun May 4 22:43:11 2008

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