Utrecht17
From Proteopedia
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==Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes== | ==Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes== | ||
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The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant <scene name='80/806481/Peptide/1'>peptide</scene> from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.<ref>PMID: 11376336</ref> | The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant <scene name='80/806481/Peptide/1'>peptide</scene> from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.<ref>PMID: 11376336</ref> | ||
Revision as of 11:17, 19 January 2020
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
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References
- ↑ Lee KH, Wucherpfennig KW, Wiley DC. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol. 2001 Jun;2(6):501-7. PMID:11376336 doi:10.1038/88694
